Dual energy computed tomography in tophaceous
The classic history and examination findings of gout include previous attacks of gouty arthritis, tophaceous
deposits, joint swelling, and occasional pain.
In a retrospective review of MRIs from 30 patients with tophaceous
gout involving the knee, typical patterns and locations of MSU crystal deposition were characterized.
The syndrome in these patients develops in association with either tophaceous
compression or gouty tenosynovitis.
It has been licensed by the US Food and Drug Administration (FDA) for refractory tophaceous
31) A daily dose greater than 300 mg is often needed to achieve the target sUA level, particularly in those with moderately severe tophaceous
However, if the patient has moderate tophaceous
gout or chronic gouty arthropathy, it's appropriate to place the patient on pegloticase (Krystexxa) while discontinuing all other urate-lowering agents.
M2 PHARMA-January 9, 2013-Savient Pharmaceuticals Inc's KRYSTEXXA approved in the EU for chronic tophaceous
gout(C)2013 M2 COMMUNICATIONS
It also is possible to develop what is called chronic tophaceous
gout, which can cause joint damage and loss of motion.
Chronic gout is often associated with the development of tophaceous
deposits within cartilage, synovial membranes, bursae, and tendons.
The clinical manifestations of gout (acute gouty arthritis, gouty arthropathy, chronic tophaceous
gout, uric acid urolithiasis, and gouty nephropathy) result from deposition of monosodium urate or uric acid crystals from supersaturated body fluids.
The fourth and most disabling stage is chronic tophaceous
gout, a condition that can develop over a period as long as 10 years.