tophus

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tophus

[′tō·fəs]
(medicine)
A localized swelling principally in cartilage and connective tissues in or adjacent to the small joints of the hands and feet; occurs specifically in gout.
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References in periodicals archive ?
When one includes podagra and the presence of tophi, the specificity increases.
These findings were evident in this patient at the time of surgery even though imaging studies had not suggested gouty arthritis, and the patient did not have evidence of subcutaneous tophi.
Gouty tophi are mostly of low- or intermediate-signal intensity on T1W images and reveal an increase in signal intensity after intravenous administration of gadolinium.
1), (3) Although tophi can be deposited within a joint, the imaging characteristics of such intra-articular tophi are rarely reported and not well known.
Tophaceous gout of the cervical spine without peripheral tophi.
Gouty tophi involving the external ear may occur in the helix and antihelix, presenting as firm nodules that may ulcerate.
Our patient presented with tophaceous gout of the spine in the absence of peripheral tophi and without a previous history of gouty arthritis.
It is unknown whether tophi were resolved in patients at other investigational sites as clinical outcome measures were not part of the phase 2 protocol design.
Doctors may also find it helpful to examine joint or tophi deposits to diagnose gout.
The new criteria are based on a systematic review of the literature on advanced gout imaging; a diagnostic study in which the presence of MSU crystals in synovial fluid or tophi was the gold standard; a ranking exercise of paper patient cases; and a multicriterion decision analysis exercise.
Periorbital and/or peripheral oedema, pallor, gouty tophi, arthritis, signs of collagen vascular disease and macroglossia (amyloidosis).
Urate crystals in joints can trigger acute arthritic flares, chronic destructive arthropathy, and formation of tophi.