tophus

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tophus

[′tō·fəs]
(medicine)
A localized swelling principally in cartilage and connective tissues in or adjacent to the small joints of the hands and feet; occurs specifically in gout.
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Tophi can be gradually dissolved and decreased in size after active ULT to maintain the serum urate level below 300 [micro]mol/L for more than 6 months.
Additionally, only six patients presented with concomitant subcutaneous tophi.
The study compared 62 patients who had clinically apparent tophi at baseline and 23 patients who did not.
Since the trial was 12 months long, the time over which serum urate was less than 6 mg/dL was not long enough to demonstrate the benefits on flares and tophi," she said.
Tophi were present in bilateral second metacarpals and the left elbow.
The Rome prediction rule requires meeting 2 of 3 criteria: serum uric acid >7 mg/dL in men and >6 mg/dL in women, presence of tophi, and history of attacks of painful joint swelling with abrupt onset and resolution within 2 weeks.
Carpal tunnel syndrome caused by gouty tophi is not rare, its incident reported to be approximately 0.
The tophi may rupture, exposing the monosodium urate (MSU) crystals to circulating macrophages.
Treatment is lifelong, but maintaining urate levels at <6 mg/dL will result in tophi resolution over time and a reduction in acute attacks of gout.
Galen (Claudius Galenus of Pergamon), described the gouty tophi and associated this disease with hedonism and overindulgence; he could not help seeing a hereditary trait in it all.
Occasionally large tophi can cause ulceration (Weinfeild et al 1998).
In long-standing gout, deposits of uric acid crystals may collect in the earlobes and the soft tissues of the hands, forming small, creamy lumps called tophi.