tophus


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to tophus: hyperuricemia, gout

tophus

[′tō·fəs]
(medicine)
A localized swelling principally in cartilage and connective tissues in or adjacent to the small joints of the hands and feet; occurs specifically in gout.
Mentioned in ?
References in periodicals archive ?
Painful bipartite patella secondary to a gouty tophus was first reported by Hiroyuki Enomoto in 2006.
6) Of the 32 knees, 26 had multiple lesions, while only 6 had a single isolated tophus.
With the advent of the disease, a tophus may cause persistent pain that impairs foot function, superimposed infection and uncontrolled drainage, or enlargement of a digit.
Radiologic case study: Gouty tophus involving the distal quadriceps tendon.
Orienting Joseph's left foot directly toward the viewer, as Martini has done, gives the tophus the greatest degree of visual emphasis.
The presence of monosodium urate monohydrate crystals in a symptomatic joint, bursa, or tophus is sufficient to diagnose gout, according to new gout classification criteria from the American College of Rheumatology and the European League Against Rheumatism.
The crystals then promote further degradation of the cartilage matrix through tophus formation and inflammation.
The hyperintense signal intensity seen on T2W spin-echo images may reflect the high protein content in the amorphous center of the tophus, while the decreased signal intensity may indicate regions of calcification within the tophus, fibrous tissue and crystals, hemosiderin deposition, or proton immobility.
The clinical diagnosis of gouty tophus is easily established if the clinical and radiologic features are classic.