Keywords: Helichrysum aureonitens; Galangin; Flavonol; Antibacterial activity; 4-quinolone; Topoisomerase
; Staphylococcus aureus
Snapka, DNA polymerase and topoisomerase
IIinhibitors from Psoralea corylifolia, J.
Level of DNA topoisomerase
IIa mRNA predicts the treatment response of relapsed acute leukemic patients.
As in genomic DNA, replication and transcription processes exert topological stresses on mtDNA molecules which are relieved by native topoisomerases
Levens, "DNA topoisomerases
: beyond the standard role," Transcription, vol.
This study was performed to elucidate the role of a topoisomerase
I inhibitor (topotecan) in the treatment of chemoresistant ovarian cancer-initiating cells.
Zylka said that a temporary exposure to a topoisomerase
inhibitor in utero has the potential to have a long-lasting effect on the brain, by affecting critical periods of brain development.
Camptothecine (CPT), a quinoline alkaloid, is a potent inhibitor of the eukaryotic topoisomerase
I (Hsiang et al., 1996; Baikar and Malpathak.
Quinolone resistance in Gram-negative pathogens is usually acquired by chromosomal mutations, primarily in the quinolone resistance-determining regions (QRDRs) of the target genes, gyrA and gyrB, which encode DNA gyrase, and parC and parE, which encode topoisomerase
In addition, an important aspect of the choice of topotecan was its effect on a vital cellular process, namely, the role of topoisomerase
I on DNA processes.
Instead, drugs that inhibit the activity of DNA-unwinding proteins called topoisomerases
did the trick.