Being able to isolate stable populations of totipotent cells
in culture would therefore be highly valuable for research and have potential medical significance.
However, cells collected to develop into stem cell lines for research are not the totipotent cells
found in the very beginning of development.
ANT, as described above with the combination of alterations in Cdx2 and Nanog, would not only preclude the establishment of the gene expression pattern of a totipotent cell
, but would also initiate the transformation of the somatic cell nucleus directly toward the epigenetic configuration of a pluripotent stem cell.
Since a totipotent cell
can develop into a complete organism, it could be considered an embryo.
In a culture of embryonic stem (ES) cells, a small population (around one percent) spontaneously turns into cells that are similar to the totipotent cells
of the 2-cell stage embryo.
They can be classified as totipotent cells
, naive pluripotent stem cells, primed pluripotent cells, and tissue-specific multipotent stem cells.
However, the BIA revealed however, quite alarming fat mass values, probably correlated to a greater differentiation of totipotent cells
into adipocytes, which occurs when excessive food intake happens during the growth phase.
It also increases the count of totipotent cells
positive for the CD133 antigen.
The question asked whether a parthenote, which only contained pluripotent and not totipotent cells
and was therefore incapable of developing into a human being, was included in the term "human embryo" under Article 6(2)(c) of the Directive.
Sacrococcygeal teratoma arises from the totipotent cells
of the caudal cell mass.
In contrast to a fertilized human ovum, which gives rise to totipotent cells
and possesses the inherent capacity to develop into human beings given the right environment, chemically activated oocytes or "parthenotes" arc pluripotent and, therefore, incapable of ultimately developing into human beings.