Cause, clinical course and complications in patients with Stevens-Johnson syndrome and Toxic Epidermal Necrolysis
. Res Med.
Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis
: A retrospective study on patients included in the prospective EuroSCAR Study.
Mei, "Retrospective analysis of stevens-johnson syndrome and toxic epidermal necrolysis
in 88 Chinese patients," Chinese Medical Journal, vol.
Cohen, "Stevens-Johnson syndrome and toxic epidermal necrolysis
: a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures," Advances in Therapy, vol.
Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis
. Exp Ther Med 2015;10:519-24.
Steven Johnson syndrome and toxic epidermal necrolysis
are immune-mediated reactions, due to various etiological factors like drugs, infections, malignancy and radiation therapy; however drugs are most commonly implicated in 95% of cases1.
Sheu, "Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis
: acute ocular manifestations, causes, and management," Cornea, vol.
Jankovic et al., "TNF-[alpha] and IFNy are potential inducers of fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis
," Journal of Investigative Dermatology, vol.
Material and Methods: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis
and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludag University School of Medicine were included in this study.
They cover pathophysiology; evaluation, resuscitation, and treatment; wound care, use of antibiotics, and control of burn wound sepsis; nutrition; inhalation injury; general (nonburn) inpatient wound care; toxic epidermal necrolysis
syndrome and Stevens-Johnson syndrome; chemical burns; and pediatric burn management.
Emergency physicians must be able to recognize a handful of life-threatening dermatologic conditions, e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis
, and staphylococcal scalded skin syndrome; however, the vast majority of dermatoses in patients who come to emergency departments are not urgent and often go undiagnosed.