After the biopsy was performed on the 22nd day of transplantation, histopathological analysis of the specimen confirmed the diagnosis of toxic hepatitis
. Stool examination was repeated 8 d after the diagnosis and was negative.
The CIOMS/RUCAM scale was used to objectively evaluate the probability of toxic hepatitis
; it showed a "likely" correlation with a 5-point score, which confirmed the diagnosis of albendazole-induced toxic hepatitis
with a pattern of hepatocellular damage.
Male Wistar rats, weighting 150-200 g, were used in the modulation of experimental toxic hepatitis. All experimental procedures were performed according to the international rules for humane treatment of laboratory animals and in accordance with the sanitary rules for maintenance of experimental biological clinics (vivarium).
However, question concerning ROS level change under experimental toxic hepatitis development remains unclear.
The level of diene conjugates was 1.47 and 1.70 times higher than in control at 110 and 125 h of experimental toxic hepatitis development, respectively.
In the present report, the development of seizures may be related to the toxic hepatitis, secondary to hypoglycemia, associated to hypoxia caused by ventricular tachycardia or effect of prostaglandin administration.
In the present case, ALT was increased more than ten times, indicating severe hepatic damage, compatible to acute toxic hepatitis. In view of the complementary exams and clinical signs, the diagnosis of acute toxic hepatitis, probably caused by prostaglandin administration was suggested.
RELEVANCE TO CLINICAL OR PROFESSIONAL PRACTICE: In the industrial waste treatment process, the danger of developing toxic hepatitis should be kept in mind, because any subtle change of the treatment process can generate various toxic materials and threaten the workers' health.
KEY WORDS: complex exposure, dimethylacetamide, hepatotoxicity, industrial waste, liver biopsy, toxic hepatitis. Environ Health Perspect 115:107-112 (2007).
The soccer hero has been sedated in an Argentinian clinic suffering from toxic hepatitis
caused by alcohol abuse.
Cases of acute toxic hepatitis
in two patients--one in California and one in Texas-- have been attributed to ingestion of an herbal nutritional supplement product derived from the leaves of the creosote bush known commonly as chaparral.
He is reportedly suffering from acute toxic hepatitis