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Hypertrophy and dilation of the colon associated with prolonged constipation.



in man, enlargement of part or all of the colon.

Megacolon usually originates with congenital immaturity of the colon’s innervation apparatus. The clinical course of the condition is characterized by persistent constipation beginning in the first years (sometimes in the first months) of life. This, the most common form of megacolon, is called Hirschsprung’s disease. In adults, megacolon may be caused by the presence of mechanical obstructions (tumor, cicatricial stenosis). Treatment is surgical.

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Ulcerative crepitus"--a case with subcutaneous emphysema and pneumomediastinum without colonic perforation or toxic megacolon in ulcerative colitis successfully treated conservatively.
Surgery is a last resort for the treatment of unmanageable CDAD with toxic megacolon or colon perforations.
Patients with severe pseudomembranous colitis such as toxic megacolon and patients who have surgical intervention are more likely to have a leukemoid reaction.
Complicated CDAD includes hypotension, ileus, toxic megacolon or colonic perforation.
With this therapeutic concept in mind, HBOT was tried previously with successful results in a patient with toxic megacolon.
Clostridium difficile is a spore-forming bacterium that can invade the intestines and cause severe diarrhea, colitis (inflammation of the large intestine), toxic megacolon (severe inflammation and distention of the large intestine), sepsis (life-threatening infection in the bloodstream), bowel perforation and, in the most serious cases, death.
PREPOPIK is contraindicated in the following conditions: patients with severely reduced renal function, gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, or in patients with a known allergy to any of the ingredients in PREPOPIK.
difficile as the causative agent of antibiotic-associated diarrhea, pseudomembranous colitis, and toxic megacolon, is a major cause of healthcare-associated infection.
To prevent the risk of precipitating a toxic megacolon, loperamide should not be given to severely ill patients.
MOVIPREP should also be used with caution in patients with severe ulcerative colitis, ileus, gastrointestinal obstruction or perforation, gastric retention, toxic colitis, or toxic megacolon.
In some patients with toxic megacolon who require surgical intervention or colectomy, mortality can reach even higher rates of 35-50%.