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Hypertrophy and dilation of the colon associated with prolonged constipation.



in man, enlargement of part or all of the colon.

Megacolon usually originates with congenital immaturity of the colon’s innervation apparatus. The clinical course of the condition is characterized by persistent constipation beginning in the first years (sometimes in the first months) of life. This, the most common form of megacolon, is called Hirschsprung’s disease. In adults, megacolon may be caused by the presence of mechanical obstructions (tumor, cicatricial stenosis). Treatment is surgical.

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Dr Ing presented a case study in which a 20-year-old girl with ulcerative colitis developed toxic megacolon, resulting in her large bowel being surgically removed.
Toxic megacolon with colonic perforation complicating Campylobacter jejuni ileo-colitis.
difficile colitis, including peritonitis, toxic megacolon, sepsis, acute renal failure, and systemic inflammatory response syndrome.
Antimotility agents are not indicated, since they impair host responses and increase the risk of toxic megacolon.
Loperamide-related toxic megacolon in Clostridium difficile colitis.
In general there are two potential life-threatening manifestations of UC -- toxic megacolon and colorectal cancer.
A: The condition is marked by several steps: diarrhea -- and consequent dehydration; fever when the inflammatory process is entrenched; arthritis of the medium-sized joints; eye inflammation; skin lesions; progressively severe bleeding causing anemia; loss of protein and swelling; and development of a toxic megacolon as the severity of inflammation spreads throughout the bowel.
Never allowing irritant laxative use, as there is an increased risk of laxative habit, toxic megacolon and possibly GI cancer in long-term users of drugs such as Dulcolax, Ex-Lax, Per-Diem, Senokot and other irritant laxatives.
At the hospital, toxic megacolon and septicemia were diagnosed, and the patient underwent immediate surgery to remove his entire colon and perform an ileostomy.