Although the algorithm was directed only to assess the chemicals' level of toxicity
when consumed orally, the researchers conclude that their strategy can be extended to predict other types of toxicity
Frequent manifestations of amiodarone-related plulmonary toxicity
include subacute diffuse interstitial pneumonia, eosinophilic pneumonia, and pulmonary fibrosis while multiple lung nodules, diffuse alveolar injury, AC edema with/without ARDS, diffuse alveolar hemorrhage, bronchospasm, and pleural effusion are rare manifestations.
The use of data from the NRU cytotoxicity assay within a Weight-of-Evidence (WoE) assessment is one of the choices for adapting the standard information requirements for acute oral toxicity
, as described in the last update of the ECHA's guidance on Information Requirements and Chemical Safety Assessment.
Some MTX experts recommend the use of vitamin A to combat recalcitrant GI toxicity
Associated hazards include: acute toxicity
, irritation, liver toxicity
and kidney toxicity
Diagnosing copper toxicity
is no easy feat because the condition is often only spotted through tissue or blood and urine samples.
In conclusion, it is imperative that health care providers maintain a high index of suspicion for PG toxicity
while treating patients receiving PG-containing medications and consider surveillance osmol gap monitoring for prevention and early intervention of clinical toxicity
, particularly in the face of hyperosmolar anion gap metabolic lactic acidosis with electrocardiogram findings consistent with ischemia.
Two types of acute toxicity
test batteries (aquatic and soil) are proposed for solid waste and LL in Germany after 2005-2007 European inter-laboratory comparison ring test (Wilke et al.
(18) However, the typical resuscitative measures employed in the setting of an acute, non-local anesthetic, lipophilic drug toxicity
have varied and were based on the suspected class of overdosed drug.
Vemurafenib, which is approved for the treatment of unresectable stage III-IV BRAF mutant melanoma, is commonly associated with skin toxicity
, with severe cases occurring only rarely; the impact of severe forms of toxicity
on treatment and patient outcomes was unknown, the investigators said.
(2) In fulfillment of that mission, the AIPH Toxicology Portfolio is charged with evaluating the toxicity
of specific military-unique chemicals in materials entering the Army supply system.
The purpose of the study is to compare effectiveness, safety, and toxicity
profile of conventional HDR-BT and once a week and twice a week HDR-BT study concurrent with EBRT