Open Competition: Open Tender For The Right To Conclude An Agreement On Scientific-Research Work Preclinical Toxicological Study
Of The Drug On The Basis Of Tetrodotoxin Contest Number 1
The data will be used in support of a GLP toxicological study
design considerations include species selection (default to rat and dog) and pharmacological considerations, compound metabolic/PK profile; testing of the quality of the drug candidate; formulation; dose-exposure linearity information; study duration; clinical endpoints (clinical observations, body weight, food consumption); pathology endpoints (clinical pathology and gross and histopathology) and toxicokinetics.
Assessing the human health effect of any given chemical requires careful epidemiological and toxicological study
, which has not been conducted for most drinking water contaminants.
In 2006, Fornaciari questioned the results of a toxicological study
that pointed to arsenic poisoning as the cause of Francesco's death.
1971) carried out a toxicological study
in rats and dogs for the detection of chronic toxicity on application of high doses of a combination product with synthetical D,L-kavain (Hapke et al.
BEUC also stated that products are not subjected to an in-depth toxicological study
Having reviewed both a 90 day inhalation toxicological study
followed by a supportive two generation reproduction study it has been accepted that a no adverse effect level (N.
The toxicological study
is to be conducted by the National Academy of Sciences (NAS) and paid for with $500,000 included in the CPSC's fiscal year 1999 appropriation.
Concerned that sea turtles might be affected by this oil, especially off their nesting beaches in the southern United States, the Interior Department commissioned a consortium of research institutions to conduct the first toxicological study
of oil's effects on these aquatic reptiles--all of which are either endangered or threatened species.
A twelve-month toxicological study
(on mini pigs) was completed during the summer.
The potential effect of hypertension on the manifestation of PM-related cardiovascular effects is supported by a toxicological study
conducted in a rat model of hypertension, which demonstrated that [PM.