toxicological study

toxicological study

[‚täk·sə·kə‚läj·ə·kəl ′stəd·ē]
(medicine)
The study of how much poison must be present to produce an effect on animals or plant systems, may also include what type of effect is produced and how it is detected.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Assessing the human health effect of any given chemical requires careful epidemiological and toxicological study, which has not been conducted for most drinking water contaminants.
Toxicological study design considerations include species selection (default to rat and dog) and pharmacological considerations, compound metabolic/PK profile; testing of the quality of the drug candidate; formulation; dose-exposure linearity information; study duration; clinical endpoints (clinical observations, body weight, food consumption); pathology endpoints (clinical pathology and gross and histopathology) and toxicokinetics.
BEUC also stated that products are not subjected to an in-depth toxicological study. However, formulators of air fresheners evaluate products for health and safety and consumer specialty products in the U.S.
Having reviewed both a 90 day inhalation toxicological study followed by a supportive two generation reproduction study it has been accepted that a no adverse effect level (N.O.A.E.L.) is at the level 400ppm (parts per million).
The toxicological study is to be conducted by the National Academy of Sciences (NAS) and paid for with $500,000 included in the CPSC's fiscal year 1999 appropriation.
Concerned that sea turtles might be affected by this oil, especially off their nesting beaches in the southern United States, the Interior Department commissioned a consortium of research institutions to conduct the first toxicological study of oil's effects on these aquatic reptiles--all of which are either endangered or threatened species.
The potential effect of hypertension on the manifestation of PM-related cardiovascular effects is supported by a toxicological study conducted in a rat model of hypertension, which demonstrated that [PM.sub.2.5] CAPs exposure resulted in higher mean arterial pressure compared with air controls (Sun et al.