trachoma


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to trachoma: inclusion conjunctivitis

trachoma

(trəkō`mə), infection of the mucous membrane of the eyelids caused by the bacterium Chlamydia trachomatis. Trachoma affects at least 86 million people worldwide. An estimated 1.9 million people are blind or visually impaired because of it, making the disease the second leading cause of blindness, after cataracts. It is most common in parts of Africa, the Middle East, and Asia, typically occurring in the poorest, most rural areas. In the United States it has occurred sporadically among Native Americans and in mountainous areas of the South.

Trachoma is highly contagious in its early stages and is transmitted by direct contact with infected persons or articles (e.g., towels, handkerchiefs) and also by flies. It begins as congestion and swelling of the eyelids with tearing and disturbance of vision. The cornea is often involved. If left untreated, scar tissue forms, which causes deformities of the eyelids and, if there is corneal involvement, partial or total blindness. The disease has been effectively treated with tetracycline ointment and with the newer oral drug azithromycin (Zithromax). The World Health Organization began a campaign in 1998 to eradicate the disease worldwide by the year 2020. The strategy includes use of azithromycin and sanitation improvements in water supplies. A number of countries have made significant progress against the disease, and some have eliminated it entirely.

Trachoma

 

a chronic infectious disease of the eyes marked by inflammation and thickening of the conjunctiva and subsequent scarring. The causative agents are chlamydiae, microorganisms similar to viruses, that reproduce in the epithelial cells of the conjunctiva and often form colonies enveloped in a covering. The disease is transmitted from infected to noninfected eyes by flies, the hands, and such objects as handkerchiefs, towels, and washbowls contaminated by pus, mucus, or tears. The incubation period lasts from seven to 14 days. Both eyes are generally affected.

Trachoma can be divided into four clinical stages. The first stage is marked by inflammatory infiltration of conjunctival tissues, the appearance of semitransparent follicles in this tissue’s retrotarsal folds and on the eyelid conjunctiva, and the discharge of mucus and pus. In the second stage, these symptoms intensify and signs of scarring appear. The third stage is marked by severe scarring, and the fourth, by permanent scarring, the arrest of follicle formation and tissue infiltration, and cessation of the disease itself.

If untreated, trachoma may persist for years and even decades. The cornea often becomes affected by pannus, and a suppurative ulcer of the cornea may occur if trachoma is accompanied by a secondary infection. The spread of infiltration and scarring to the eyelid and tendons causes ptosis of the upper eyelid or inversion of the eyelids, resulting in ingrowing eyelashes (trichiasis) and traumatic injury to the cornea. Scarring of the conjunctival sac may lead to the fusing of the conjunctiva with the eyeball. Xerophthalmia is a possible consequence of trachoma. The extent of visual impairment is directly related to the degree of injury to the cornea.

Trachoma is treated with antibiotics, sulfanilamides, and such enzymes as hyaluronidase. Surgery is indicated in trichiasis and some other complications and consequences of trachoma.

The incidence of trachoma is determined by the economic and cultural level of a given area and the prevailing sanitary conditions. The disease is most widespread in Asia and Africa. Trachoma is prevented by early detection, systematic treatment, and the promotion of habits of personal hygiene. The disease is no longer common in the USSR owing to the effectiveness of the measures used to control it.

REFERENCES

Chirkovskii, V. V. Trakhoma, 6th ed. Moscow, 1953.
Mnogotomnoe rukovodstvo po glaznym bolezniam, vol. 2, book 1.
Moscow, 1960. Page 77. Kovalevskii, E. I. Detskaia oftal’mologiia. Moscow, 1970. Page 130. System of Ophthalmology, vol. 8. London, 1965. Page 258.

M. L. KRASNOV

trachoma

[trə′kō·mə]
(medicine)
An infectious disease of the conjunctiva and cornea caused by Chlamydia trachomatis producing photophobia, pain, and excessive lacrimation.

trachoma

a chronic contagious disease of the eye characterized by inflammation of the conjunctiva and cornea and the formation of scar tissue, caused by infection with the virus-like bacterium Chlamydia trachomatis
References in periodicals archive ?
Prof Promila Gupta, Principal Consultant, dealing with the National Programme for Control of Blindness and Visual Impairment, told ANI: "Our results have suggested that active trachoma is no longer a public health problem in the country as India has eliminated the trachoma disease.
Yet trachoma is totally preventable., Sightsavers distributes an antibiotic to treat trachoma at a cost of as little as 15p per treatment.
Secondly, it states "the trachoma prevalence was high among infants (1-5 year) and more prevalent among female children 82 vs 75".
Trachoma is rife in West Pokot due to the unique relationship the pastoralists have with their animals.
All 4 patients used natural depilatory wax to improve their trachoma. No additional information on use of traditional eye medicine or epilation was obtained.
Hotel Muscat today a certificate on validation of elimination of trachoma
In 2002, the Nepal government launched a national trachoma programme and implemented a series of sustained control activities that reduced the prevalence of active (inflammatory) trachoma by 40 per cent till 2005.
In Saudi Arabia there has been a remarkable decrease in the prevalence of trachoma.52 The incidence of trachoma was found to be very low in the western Saudi Arabia53 and as well as in the eastern province.54 Onchocerciasis is another major infectious cause of blindness in many African countries, Yemen and some countries in Latin America.
Trachoma causes a roughening of the inner surface of the eyelids.
The Department for International Development said that it is hoped the money will help eliminate trachoma - a bacterial eye infection - in Commonwealth countries by 2020.
The Department for International Development said it is hoped the money will help eliminate trachoma - a bacterial eye infection - in Commonwealth countries by 2020.