Transaminase


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transaminase

[¦tranz′am·ə‚nās]
(biochemistry)
One of a group of enzymes that catalyze the transfer of the amino group of an amino acid to a keto acid to form another amino acid. Also known as aminotransferase.

Transaminase

 

(also aminotransferase and aminopherase), an enzyme of the transferase group that catalyzes the transfer of an amino group (—NH2) from an α-amino acid to an α-keto acid. Transaminases are found in most animal and plant tissues and play an important part in nitrogen metabolism. The role of transaminase in the transamination process was discovered by the Soviet biochemists A. E. Braunshtein and M. G. Kritsman in 1937. The coenzyme in transaminase reactions is pyridoxal phosphate, the aldehyde group of which serves as intermediate acceptor of the amino group. The resulting pyridoxamine phosphate transfers the amino group to the ketone group of the acid undergoing amination. The reaction is reversible.

A. A. BOLDYREV

References in periodicals archive ?
The high transaminases and the absence of significant alkaline phosphatase elevation can be confusing.
In line with other reports, the increased transaminases in our case also resulted in referral to the Hepatology and Gastroenterology Department for examination and evaluation; and muscle disease did not cross the mind of the assessing physician (5,6).
Evaluations of activities of enzymes (acid and alkaline phosphatases, alanine and aspartate transaminases, lactate, and glucose-6-phosphate dehydrogenases) were carried out in the samples collected.
The patient we report was hospitalized within 32 days of nonspecific clinical manifestations (leukopenia, anemia, thrombocytopenia, increased serum transaminase concentrations, and hepatosplenomegaly), which have been reported for persistent infection (10).
Creasey et al., "The association of alanine transaminase with aging, frailty, and mortality," Journals of Gerontology--Series A Biological Sciences and Medical Sciences, vol.
Drug-induced liver injury has become the leading cause of acute liver failure and transplantation in Western countries.1,2 It has been observed that when experimental animals are treated with anti-tuberculosis drugs, a correlation exists between hepatic injury and oxidative stress (OS).3,4 Levels of alanine transaminase (ALT) and bilirubin are helpful in the diagnosis of hepatic diseases.3
Although laboratory tests used in first-aid health units, such as hemogram and transaminase dosages, give a laboratory profile of the patient suspected of dengue, probably in its more acute phase, they do not provide a safe and differential diagnosis with other viroses.
Accordingly, the prevalence of suspected statin induced hepatic effect was 4% in the study population and significant transaminase rise (> 3 times) was observed only in 1% of the patients.
In the current study, although all the patients had mild to moderate fibrosis and minimal to mild activity in liver biopsy, nearly half of them had normal transaminases. It has been reported that alanine transaminase levels were normal in half of the subjects, yet, histological abnormalities were detectable in three quarters of HCV-RNA positive cases [5].
Blood samples from 34 albino mice (18 CGP55845 treated and 16 saline treated) were collected from direct cardiac puncture and various hematological parameters such as blood glucose, packed cell volume (PCV), total WBC (TWBC) count, total RBC count and serum biochemical parameters, such as cholesterol, aspartate transaminase, alanine transaminase (ALAT) high density
The companies have completed multiple projects in the fields of ketoreductase, transaminase, biooixdation and hydrolase.
In this study we compared sensitivity, specificity and diagnostic efficiency of serum Sialic acid with other traditional markers like AST (Aspartate amino transaminase), ALT (Alanine amino transaminase), GGT (Gamma Glutamyl Transferase), as a marker of alcohol abuse.