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Any of various enzymes that catalyze the transfer of a chemical group from one molecule to another.



any of a class of enzymes that catalyze the transfer of a chemical group from one compound (the donor) to another (the acceptor). Transferases are common in plant and animal tissues, as well as in microorganisms. They play a leading role in intermediary metabolism, participating in the transformations of carbohydrates, amino acids, nucleic acids, lipids, and other biologically important compounds.

The transferase class includes more than 450 enzymes, divided by the chemical nature of the group being transferred into subclasses. Examples include the subclasses that catalyze the transfer of single-carbon groups (methyltransferases), glycosyl groups (glycosyltransferases), nitrogen-bearing groups (aminotransferases, or transaminases), and phosphate groups (phosphotransferases). The transferases of the various subclasses have different coenzymes.

The mechanism of the catalytic action of the transferases studied to date includes the formation of an intermediate made up of the enzyme and group being transferred. For example, in the transfer of the acetyl radical (CH3CO—), an acetylated enzyme is formed in the first stage of the reaction, followed by the transfer of the radical to the acceptor and the liberation of the enzyme. The names of transferases are formed according to the sequence dononacceptor-transferred group-transferase. For example, the enzyme that catalyzes the transfer of the phosphate group from adenosinetriphosphate (ATP) to creatine is called ATP:creatine-phosphotransferase. Several transferases have been obtained in crystalline form.


Nomenklatura fermentov. Moscow, 1966. (Translated from English.)
Kretovich, V. L. Vvedenie v enzimologiiu, 2nd ed. Moscow, 1974.


References in periodicals archive ?
In addition, new programs in protein engineering (37) of subtilisin BPN' (3,38-50) and hemoglobin (7,51-56) were carried out as well as detailed structural investigations of a number of enzymes that included ribonuclease (57-64), several glutathione S-transferases (6,65-82), uracil DNA glycosylase (8,83-84), threonine deaminase (85-86), and nucleoside diphosphosphate transferase (87-88).
Purification and characterization of a recombinant human Theta-class glutathione transferase (GSTT2-2).
To compare the serum Gamaglutamyl transferase activity, and lipid ratios in myocardial infarction patients and healthy subjects.
Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae.
This case supports the view that early epidural analgesia, glucose supplementation and good hydration are strategies which should reduce the risk of labour-induced rhabdomyolysis in patients with carnitine palmitoyl transferase deficiencies.
Half of the 22 patients studied had pronounced abnormalities: jaundice in 4, [gamma]-glutamyl transferase higher than four times the normal value in 10, alkaline phosphatase higher than twice the normal value in 7, and transaminases higher than three times the normal value in 7.
Hepatocellular integrity in liver donors and recipients indicated by glutathione transferase a.
New Haven, CT, announced the US Patent and Trademark Office has issued a patent a covering the company's cloned pig gal transferase gene.
One of the genotypes appeared to increase the association between DBPs and bladder cancer codes for the active form of the enzyme glutathione transferase theta-1 (GSTT1), which metabolizes brominated THMs to mutagens.
Also disclosed are a recombinant 1,2-mannosyltransferase that is enzymatically active, is dispersible in an aqueous reaction medium, and free of the transmembrane portion of the native enzyme, as well as DNA encoding that transferase, an expression vector containing exogenous DNA that encodes that enzyme and E.
Other topics of the 29 papers include the three mammalian glutathione transferase families, the clinical development of histone deacetylase inhibitors, the molecular mechanisms of hepatic fibrosis, and signaling networks in living cells.