Transferrin


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Related to Transferrin: Transferrin saturation, TIBC

transferrin

[′tranz′fer·ən]
(biochemistry)
Any of various beta globulins in blood serum which bind and transport iron to the bone marrow and storage areas.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Transferrin

 

(also siderophilin), any of a group of related complex proteins (glycoproteins) that transport Fe3+ iron ions in organisms. The carbohydrate component of transferrins constitutes approximately 5.5 percent. The molecular weight is approximately 80,000.

Transferrins occur in blood plasma, milk, and egg albumin (conalbumin). In blood plasma, their main functions are the transport of iron (with one molecule of transferrin binding two atoms of trivalent iron) to the reticulocytes, where hemoglobin is synthesized, and the maintenance of the Fe2+/Fe3+ ratio at a certain level. Upon electrophoresis of plasma proteins, transferrin is found in the β-globulin fraction. Transferrins are found in various genetically dependent forms, which have similar physical and chemical properties. A deficiency of transferrin in organisms leads to a number of pathological states caused by disruption of iron metabolism.

REFERENCE

Glikoproteiny, vol. 2. Moscow, 1969. (Translated from English.)
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Effect of glycan structure on physicochemical properties and functions of transferrin
In contrast, transferrin saturation levels of C282Y homozygous patients were consistently higher than levels in patients without C282Y (Welch unequal variances t test, 2-tailed P < .001).
Moreover, urine albumin, uACR, urine NGAL and NGAL/creatinine ratio, urine transferrin, urine IgG, urine uromodulin, and uromodulin/creatinine ratio significantly correlated with diabetes control as reflected by HbA1c concentrations.
Chung, "Structure and function of transferrin," Biochemical Education, vol.
Serum ferritin (Cat # BC-1025; BioCheck, United States) (reference range: male: 28-365 ng/dl; female: 5-148 ng/dl) and soluble transferrin receptor (Cat # YHB2785Hu, YH Bioresearch China) (reference range: male: 2.2-5.0 mg/L; female: 1.9-4.4 mg/L) were measured by commercially available enzyme-linked immunosorbent assay (ELISA) kits method.
However, the iron from different states such as absorbed iron in duodenal enterocytes or stored within hepatocytes or recycled by macrophages; ultimately pass from cytoplasm of cells to the transferrin (Ganz et al., 2012), and iron efflux from cells is facilitated via a multipass transmembrane protein i.e., iron exporter ferroportin 1 (Donovan et al., 2005).
We used the Tfr2 KI animals ([[alpha].sup.+] [[beta].sup.0]]), in which circulating iron levels are normal, and the Tfr2 KO mice ([[alpha].sup.+] [[beta].sup.0]]), that have severe iron overload in addition to increased serum ferritin and transferrin saturation.
For both CRP and transferrin saturation (TSAT), the assumption of homogeneity of variances was not tenable (F < 0.05).
Serum levels of transferrin and ferritin in subjects were obtained in each trimester.
From the candidates, ENOSF1 and transferrin were selected for Western blot analyses due to their correlation with animal reproduction.
Transferrin may be considered as suitable candidate for targeting drug delivery due to its non-toxic, biodegradable, non-immunogenic properties as well as efficient uptake through transferrin receptors.
Panther Biotechnology, a company focused on the acquisition and development of small molecule therapeutics for the treatment of Leukaemia, Lymphoma and Myeloma, has started the formal drug development process for its lead compound, Transferrin Doxorubicin, it was reported on Friday.