transgene


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transgene

[′tranz‚jēn]
(genetics)
Genetic material from one organism that has been experimentally transferred to another, so that the host acquires the genetic traits of the transferred genes in its chromosomal composition.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Transgene is convinced of the great potential of oncolytic viruses as this therapeutic class displays numerous advantages that are acknowledged by the scientific and medical community.
NEC and Transgene have capitalized on the recent progress in AI and advances in genome sequencing to create individualized immunotherapy, which is adapted to the unique characteristics of each patient's mutational landscape as well as their predicted immune responses.
All closing conditions including completion of the administrative transfer of the assets contributed by Transgene to Tasly Biopharmaceuticals have been completed and 27.4m newly-issued shares of Tasly Biopharmaceuticals valued at USD48 m have been delivered to Transgene.
(b) Genotyping of teratoma tissues derived from 6 O-iPS colonies for Cre transgene. Sorted [GFP.sup.+] osteoblasts serve as a positive control.
So what happens to the transgene, once integrated into its host cells?
Transgene's Invir.IOTM technology is an efficient way to target immunosuppressive pathways directly in the tumor microenvironment.
Transgene has a large collection of viral vectors and is renowned for its competence in the genome engineering of these vectors.
To construct the cumate-inducible transgene expression vector, the green fluorescent protein (GFP) or MyoD gene was inserted into the piggyBac cumate switch inducible vector (System Biosciences, Palo Alto, CA, USA) after NheI/NotI digestion and ligation.
If the worms were kept at 20 degrees Celsius (68 degrees Fahrenheit), the array of transgenes was less active, creating only a small amount of fluorescent protein, but when they were exposed to a warmer temperature of 25 degrees Celsius (77 degrees Fahrenheit), the activity of the transgenes was significantly increased.
For Southern blot analysis of transgene copy number, approximately 15 [micro]g of RNase A-treated rice genomic DNA was digested with SpeI and separated in 1% agarose gel along with 1 kb plus DNA marker (Gene Ruler, Thermo Fisher Scientific, Walthan, MA) in 1x TBE buffer and transferred onto the Nylon-[N.sup.+] membrane (GE Healthcare Amersham).
The sheep were fed on GM insect-resistant maize grains followed by amplification of transgene through PCR assay.
This report provides comprehensive information on the current therapeutic developmental pipeline of Transgene SA's, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.