trypanosome

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Related to trypanosomal: Trypanosomatidae

trypanosome

(trĭp`ənəsōm'), microscopic, one-celled protozoan of the genus Trypanosoma, typically living as an active parasite in the bloodstream of a vertebrate; hundreds of species are known. A trypanosome is long and pointed and possesses a flagellum. The flagellum arises at the front, or anterior, end of the parasite and curves back to form the edge of a long, undulating membrane used in locomotion. Trypanosomes have a complex life cycle; most species undergo part of their development in the digestive tract of insects, which spread the parasite by biting.

Many trypanosomes do not appear to harm their hosts, but a number of species cause serious diseases in humans or domestic animals (see trypanosomiasistrypanosomiasis
, infectious disease caused by a protozoan organism, the trypanosome, which exists as a parasite in the blood of a number of vertebrate hosts. The three variations of the disease that predominate in humans are transmitted by an insect vector.
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). T. brucei gambiense and T. brucei rhodesiense cause African sleeping sickness and are transmitted by tsetse fliestsetse fly
, name for any of several bloodsucking African flies of the genus Glossina, and in the same family as the housefly. The larva of the tsetse fly develops inside the body of the mother until it is ready to pupate in the soil.
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. T. cruzi is the cause of Chagas' diseaseChagas' disease,
disease of South and Central America caused by the parasite Trypanosoma cruzi. It usually affects children and young adults and is transmitted by the feces of infected insects, typically the assassin bug.
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, prevalent in South and Central America, which affects the nervous system and heart; it is transmitted by the bite of assassin bugsassassin bug,
common name for members of the family Reduviidae, one of the largest and most varied groups belonging to the order Hemiptera (suborder Heteroptera). Assassin bugs are generally brownish to black, medium-sized to large insects, with heads that are elongate and
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. Other species, restricted in distribution to Africa and Asia, cause diseases of horses and cattle. Control measures include elimination or reduction of the insect carrier populations and measures to reduce the likelihood of bites.

Trypanosomes are classified in the phylum Mastigophora of the kingdom ProtistaProtista
or Protoctista
, in the five-kingdom system of classification, a kingdom comprising a variety of unicellular and some simple multinuclear and multicellular eukaryotic organisms.
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.

trypanosome

[trə′pan·ə‚sōm]
(invertebrate zoology)
A flagellated protozoan of the genus Trypanosoma.
References in periodicals archive ?
Trypanosomatides occur in different morphological forms in its life cycle viz amastigote (leishmanial), promastigote (leptomonad), epimastigote (crithidial), trypomastigote (trypanosomal) and opisthomastigote (herpetomonad).
[9.] Abimbola AM, Baba IA, Yenusa EZ, Omanibe SJ, Oladimeji IH (2013) Anti- trypanosomal effect of Peristrophebicalyculata extract on Trypanosoma brucei brucei-infected rats.
Guerrero et al., "Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase," Journal of Medicinal Chemistry, vol.
The featured work by researchers, including scientists of the Max Planck Institute for Medical Research in Heidelberg, provides detailed insight into the structure of trypanosomal Cathepsin B in a natively inhibited form that might serve as a blueprint for the rational design of drugs.
In view of our patient's rapid onset of a high level of parasitemia, we investigated the possibility of a genetic susceptibility to trypanosomal infection.
(3,4) Approximately 5-15 days post-infection, a trypanosomal chancre, caused by the accumulation of trypanosomes in the connective tissue, may form at the site of the tsetse fly bite.
This case suggests that suramin toxicity may be an effect of trypanosomal decay rather than the result of direct toxicity.
Design, synthesis and evaluation of d-homophenylalanyl epoxysuccinate inhibitors of the trypanosomal cysteine protease Cruzain.
A study of tissue samples from about 300 mummies from northern Chile's ancient coastal populations indicated that 41% of those populations were infected by the fatal trypanosomal parasite that causes Chagas disease (Aufderheide et al.
brucei, there was enhanced tissue damage coupled with expression of trypanosomal procyclin, Caspase-3, -8, -9 and Bax in spleen tissue.
Nutritional therapies are often more practical and recent research has explored such methods of controlling trypanosomal infections.
Of the 20 lizards collected alive, blood was negative for plasmodial or trypanosomal parasites, and feces were negative for coccidian oocysts.