tuberculin


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tuberculin

a sterile liquid prepared from cultures of attenuated tubercle bacillus and used in the diagnosis of tuberculosis

Tuberculin

 

a diagnostic agent used to detect an allergic reaction in individuals infected with tubercle bacilli. It was first discovered by R. Koch.

Several types of tuberculin are produced in the USSR, as follows. Liquid tuberculin, or old tuberculin (OT), is prepared by boiling a bouillon culture of tubercle bacilli. Purified protein derivative of tuberculin (PPD) is prepared by adding to a filtrate of bacilli various chemical substances that precipitate proteins, and then purifying the mixture. Liquid purified protein derivative of tuberculin (PPD-L) is prepared by making standard dilutions of purified protein derivative of tuberculin. The tuberculin test detects the presence of tuberculosis; those persons who react positively should then be vaccinated against the disease. The tuberculin test serves as a means of both early diagnosis and of evaluation of the course of tuberculosis. Only the intracutaneous Mantoux test is in wide use in the USSR.

Veterinaries use the tuberculin test to diagnose tuberculosis in animals. The tuberculin is occasionally injected subcutaneously; more commonly, it is injected intracutaneously or into the conjunctival sac. Animals that react positively are considered tuberculotic. A positive reaction is manifested by inflammatory edema after an intracutaneous injection and by purulent conjunctivitis in the eye test.

tuberculin

[tə′bər·kyə·lən]
(immunology)
A preparation containing tuberculoproteins derived from Mycobacterium tuberculosis used in the tuberculin test to determine sensitization to tubercle bacilli.
References in periodicals archive ?
Two FDA-approved PPD tuberculin antigen products are available in the United States for use in performing TSTs: Tubersol (Sanofi-Pasteur) and Aplisol.
Post.exposure rate of tuberculosis infection among health care workers measured with tuberculin skin test conversion after unprotected exposure to patients with pulmonary tuberculosis: 6.year experience in an .talian teaching hospital.
We defined tuberculin conversion as an induration reaction of [greater than or equal to] 10 mm, as recommended by national and global guidelines.
Different diagnostic techniques like tuberculin testing, ZN staining, ELISA, culture isolation and PCR are conventionally used for the detection of Mycobacterium subsp.
Finally, in order to evaluate a difference in terms of positive results between PPD tuberculin mammalian and Tubertest, the two-sample Z-Test was used.
The aim of this study is, identified bovine tuberculosis animal based on tuberculin skin test; outcome of a recent intradermal infection of PPD on the sensitivity of the SICTT, in a group of cattle naturally infected with bovine tuberculosis.
Results: Out of 34 subjects, 20(58.8%) had a positive tuberculin skin test, and 7(20.6%) had a positive QuantiFERON- Tuberculosis Gold In-Tube test.
Can we improve the return rate for tuberculin skin test Readings?
There were no significant relation between tuberculin skin test positivity and presence of BCG scar (P< 0.05).
Comparison of Sensitivities and Specificities for Different Tuberculin Skin Test Induration Thresholds.
Results: Out of 800 contacts screened, 125 (15.6%) were positive on sputum smear examination while 113 had infiltration on X-rays along with positive tuberculin skin test (Indurations of greater than 10 mm) making a definitive diagnosis of TB.
Based on the sensitivity and specificity of the tuberculin skin test and the prevalence of TB in different groups, three cut-off levels of induration have been recommended by the American Thoracic Society and other study groups for defining a positive tuberculin reaction: greater than 5 mm, [greater than or equal to]10 mm, and [greater than or equal to]15 mm of induration.