tubulin


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Related to tubulin: alpha tubulin

tubulin

[′tü·byə·lən]
(biochemistry)
A globular protein containing two subunits; 10-14 molecules are arranged to form a microtubule.
References in periodicals archive ?
Duocarmycins are able to exert their mode of action at any phase in the cellular cycle, whereas tubulin binders will only attack tumor cells when they are in a mitotic phase.
Cancer cells become drug-resistant through tubulin isotype mutation and alteration of microtubule dynamics (Cheung et al.
The polymorphic sites were identified by using the standard set of ambiguity nucleotides through CLC Genomics work bench (CLC bio) and BLAST searches at NCBI/primers used to generate the AY- tubulin gene sequence from H.
This compound binds tubulin in the cancer at a site distinct from those affected by other clinically used tubulin targeting agents.
Background: Tubulin protein being the fundamental unit of microtubules is actively involved in cell division thus making them a potential anti-cancer drug target.
In a more general sense, various forms of tubulin antibodies have been used to stain neurons in cnidarians (Groger and Schmid, 2001; Galliot et al.
The objective of this study was to isolate and characterize the b- tubulin gene from B.
Some well-known housekeeping genes, such as actin, tubulin, ribosomal RNA, and elongation factor 1 alpha, are necessary for cell survival, and highly abundant proteins in all cell types.
These helical filaments composed of alpha and beta subunits of tubulin tend to be in a constant state of flux, being assembled, degraded, and re-assembled into different arrays.
15-17) The tubulin molecule is a heterodimer of [alpha]-and [beta]-tubulin, binds to GTP or GDP and is post-translationally modified by phosphorylation, tyrosination, acetylation, glycosylation, glycylation, etc.