tumor suppressor gene


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Related to tumor suppressor gene: oncogene, Proto oncogene

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
References in periodicals archive ?
The latest studies demonstrate the Ku80 gene not only controls the rate at which whole animals age, but also functions in a pathway with the p53 tumor suppressor gene.
Mutations in the p53 tumor suppressor gene are the most common genetic abnormalities found in human cancers, appearing in more than half of all cancers.
Under the terms of the agreement, Genome Therapeutics receives exclusive access to genes whose expression is regulated by the p53 tumor suppressor gene.
We have great respect for RGene's E1A tumor suppressor gene program and its innovative lipid-based gene delivery system, and we are highly positive about the potential of this collaborative program," said Dr.
Tumor suppressor genes earn their name because when they work right, they seem to keep cell growth in check.
It is regulated by a tumor suppressor gene, called p53, already known to be important in keeping some cells from forming tumors (SN: 6/5/93, p.
Cancer patients often exhibit mutations in the p53 tumor suppressor gene.
RGG0853 consists of DC-Cholesterol, RGene's lipid-based gene delivery system, complexed with E1A, a tumor suppressor gene.
p53, a tumor suppressor gene that is believed to play a pivotal role in
today announced that the United States Patent Office has issued Patent Number 5,362,623 for methods to screen for drugs that restore lost p53 tumor suppressor gene function.
Myriad recently achieved two significant milestones with the discoveries of the BRCA1 breast cancer susceptibility gene and the MTS1 multiple-site tumor suppressor gene," said Peter Meldrum, President and Chief Executive Officer.
Summary: TEHRAN (FNA)- Scientists offered hope for new cancer drugs by examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes handle cellular stress.