tumor suppressor gene


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Related to tumor suppressor gene: oncogene, Proto oncogene

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Hence, only the 15 genes with upregulated methylation and downregulated expression in early stage might be the tumor suppressor genes. The 7 genes with downregulated methylation and upregulated expression in early stage might be the cancer-promoting genes.
These proteins are then able to disrupt the function of Rb and p53, known tumor suppressor genes. p53 has been implicated in a wide variety of cancers and is known to be the target of many different viral particles.
Tumor suppressor genes are divided into two classes, the caretaker genes and the gatekeeper genes, according to the role they play.
Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers.
The VHL gene, similar to other tumor suppressor genes, follows Knudson's 2-hit hypothesis on tumorigenesis.
The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes which display a range of abnormalities with potential usefulness as markers of evolution or treatment response in cancer.
The SMAD4 gene was first identified as a tumor suppressor gene of pancreatic cancer in 1996 and was designated as DPC4 (deleted in pancreatic carcinoma, locus 4) Y The human DPC4 gene contains 11 exoras with a predicted 155 amino acid coding sequence, or just 466 base pairs.
In a study published in the July issue of the American Journal of Obstetrics and Gynecology(2000;183:39-45), the investigators found that the test could be used to identify human papillomavirus E6 and the tumor suppressor gene p53, both of which are linked to the development of cervical cancer.
The TUSC2 gene is a tumor suppressor gene, the active agent in Genprex's Oncoprex immunogene therapy.
Her doctoral thesis led to the discovery of the p53 tumor suppressor gene and the emergence of a productive new avenue of global cancer research, concluded the company.