tumor suppressor gene


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Related to tumor suppressor gene: oncogene, Proto oncogene

tumor suppressor gene

[¦tüm·ər sə′pres·ər jēn]
(cell and molecular biology)
A class of genes which, when mutated, predispose an individual to cancer by causing the loss of function of the particular tumor suppressor protein encoded by the gene.
References in periodicals archive ?
These proteins are then able to disrupt the function of Rb and p53, known tumor suppressor genes.
However, once it is a broad and complex subject, in this work the tumor suppressor genes will be particularly emphasized, with particular highlight to the p53 gene and protein.
MGI and MethylGene intend to further evaluate MG98 in cancers where silencing of tumor suppressor genes by DNA methyltransferase has been documented.
Li and Cohen's gene discovery strategy may have many uses beyond finding tumor suppressor genes.
DNA methylation is a type of epigenetic change that can result in tumor suppressor genes being inactivated.
Three patents cover gene therapy of cancer using a p53 tumor suppressor gene in combination with one or more chemotherapeutic drugs, radiation therapies, or other agents that have a damaging effect on the DNA of cancer cells.
Nairn has identified a Xiphophorus gene correlating to the p16 tumor suppressor gene in humans that seems to be associated with susceptibility to developing melanoma upon exposure to UV light.
The Columbia patent covers important clinical applications of the mda-7 gene, a tumor suppressor gene that forms the genetic basis of Introgen's second product in clinical testing.
Barely four months ago, biologists heralded the discovery of a new tumor suppressor gene, called p 16, that influenced cell growth and replication and played a key role in the development of several cancers (SN: 4/23/94, p.
Discovering REST as a tumor suppressor gene in epithelial cells led Dr.
In addition, scientists searching for causes of cancer have tied defects in the tumor suppressor gene p53 to the uncontrolled cell growth that leads to tumors (SN: 11/27/93, p.
AustCancer's Pentrys(TM) vaccine technology is based on the first synthesis of human monoclonal antibodies to the mutated p53 tumor suppressor gene protein product.