tumor suppressor protein

tumor suppressor protein

[¦tüm·ər sə′pres·ər prō‚tēn]
(cell and molecular biology)
A protein that helps protect a normal cell from becoming malignant; for example, p53.
References in periodicals archive ?
"We've known for some time that such a regulatory mechanism exists, and that the tumor suppressor protein p53 plays a key role.
Proceeds from the financing will be used to advance the clinical development of APR-246, a first-in-class anticancer agent that reactivates mutated p53 tumor suppressor protein. Aprea has commenced a Phase 3 clinical study in myelodysplastic syndromes (MDS) and has completed enrollment in a Phase Ib/II clinical trial in p53 mutated high-risk myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia (AML) with APR-246 and azacitidine.
According to the company, the proceeds from the financing will be used to advance the clinical development of APR-246, a first-in-class anticancer agent that reactivates mutated p53 tumor suppressor protein. It is planning to begin a Phase 3 clinical study in myelodysplastic syndromes (MDS) and is nearing completion of a Phase Ib/II clinical trial in p53 mutated high-risk myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia (AML) with APR-246 and azacitidine.
ALRN-6924 is a stabilized cell-permeating peptide that mimics the p53 tumor suppressor protein to disrupt the interaction with both its endogenous inhibitors, MDMX and MDM2.
Since 1993, when P16 was first identified as a cyclin-dependent kinase inhibitor, this tumor suppressor protein has gained near-universal recognition among pathologists and oncologists alike.
Under normal circumstances, BAPl is a tumor suppressor protein involved in cellular process called "ubiquitination." Often, ubiquitination serves to identify proteins "condemned" for destruction by the proteasome system.
In this study, the findings indicated that tumor suppressor protein and oncoprotein interactions represent an important role in cell fate decision between cell survival and apoptosis regulation.
FLCN encodes protein FLCN, a tumor suppressor protein which can regulate cellular activities by interacting with FNIP1 and AMP-activated protein kinase (AMPK), a key molecule for energy sensing that negatively regulates mTOR activity.
Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
For two decades, cancer researchers have looked unsuccessfully for ways to develop compounds to restore the function of mutant p53 proteins--the most important tumor suppressor protein that protects human cells from becoming cancerous.
The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another promising tumor suppressor protein, has been shown to upregulate SASH1.
Menin is a tumor suppressor protein encoded by the MEN1 gene.