References in periodicals archive ?
Methylation levels depending on DNMT1, instead, have been demonstrated to be functional for the maintenance of the lung, colon, and LSCs and to regulate their tumorigenic potential in vivo [62-64].
(77) Therefore, the reduced amounts of Lac-Cer and GM3 at the cell surface in clone E5-derived tumors can alter the cell adhesion properties and transmembrane signals that lead to the suppression of the original tumorigenic and metastatic potentials.
Hence, to explore the inhibition of GSK3beta kinase with significant repression of tumorigenic potential in glioma cell line [22], our study showed that inhibition of GSK3beta Tyrosine-216 phosphorylation activity without change in inactivated Ser9 phosphorylation leads to downregulation of the expression of GSK3beta with loss of ERK1/2 phosphorylation.
According to the CSC model, the most tumorigenic cells within such a clonal population reside at the apex of a cellular hierarchy and are capable of undergoing self-renewal to generate daughters that once again exhibit the CSC phenotype.
This has the net effect of increasing the progression of tumorigenic events.
Radial (Nontumorigenic) and Vertical (Tumorigenic) Growth Phase
Highly tumorigenic cells whose properties are consistent with those of stem/progenitors cells have been isolated from human breast cancers [23].
Although BK virus, JC virus, and simian virus 40 are tumorigenic in experimental animals and can transform mammalian cells in vitro, no convincing epidemiologic evidence exists for their role in human cancers.
If the propensity for epigenetic errors with embryo technologies that have become apparent over recent years are paralleled in human embryos, then it is important to establish the effect such errors have on tumorigenic and differentiation properties of embryonic stem cells.
The exosomes of metastatic breast cancer cells are rich in miR-200s and can enhance the metastatic ability of nonmetastatic tumor cells [35]; GBM-derived EVs are rich in many tumorigenic miRNAs, including miR-21, miR-23a, miR-30a, miR-221, and miR-451.
In this study there was no evidence of adverse proliferation, tumorigenic behavior, ectopic tissue formation, or other serious safety issues related to the transplanted cells.