Each of the planned Phase 3 studies is expected to be powered at greater than or equal to 90% to demonstrate a 30% reduction in the percentage of subjects with clinically symptomatic respiratory illness between RTB101 and placebo using a

two-sided test of 0.05 significance.

Although the alternative shows an increased weight, we compute power under a

two-sided test. To compute power, we first convert the parameters into effect size:

Statistical analysis was carried out using Fisher's

two-sided test. Differences in blood glucose with the two methods were analysed using Wilcoxon matched pairs signed ranks test.

se": statistical significance was determined using a

two-sided test (p < .05) with standard errors that assumed independently and identically distributed errors; "cluster se": statistical significance was determined using a

two-sided test (p < .05) using standard errors that were robust to hospital-level clustering; "permutation": statistical significance was determined using two-sided permutation tests (p < .05).

For assessing the null hypothesis of equality of the underlying survival distributions of the two groups, Lin and Wang propose a

two-sided test statistic based on [T.sup.*], and we will follow that convention with [T.sub.w].

(1) (95% CI,

two-sided test) for ln-transformed data, and the II was calculated as the SD of the CVa and CVi divided by the SD of the CVb.

* p < .10,

two-sided test. ** p < .05,

two-sided test.

Table 1 Study Sample Summary Sample 1 Sample 2 (1987-1998) (1999-2010) Forecasts identified by DJNRS 12,802 23,408 Firms removed due to insufficient (898) (1,201) Compustat data Firms removed due to insufficient (87) (108) CRSP data Final overall sample 11,817 22,099 Table 2 Test of Hypothesis 2 Table entry is Average Management Forecast Error Deflated by Firm's Stock Price 180 Days Prior to Forecast Model: [summation] [[fe.sub.i]/n] = 0 Panel A--Management forecast error for Pre-SLUSA period forecasts (1987-1998) Mean Median Minimum Maximum Standard (t-statistic) Deviation .11 .09 (b) .0688 .1491 .0013 (2.36) (a) (a) Significant at the 0.01 level (

two-sided test).

Dixon's test compares the individual values obtained by a single operator or the mean values obtained by several operators, or yet differences between two results obtained by several operators; it is a

two-sided test (LOPES, 2003).

Two different cases have been considered: Case 1 states that the two binomial parameters equal some specified value and yields a

two-sided test, whereas Case 2 states that the two parameters are simply equal to one another and yields one-sided or

two-sided tests.

The Washington, D.C.-based public-interest group Public Citizen says the rule should consider real-world roll dynamics rather than quasi-static testing and notes that the proposed rule ignores Congress's demand for a

two-sided test.