Rice XA21 binding protein 3 is a ubiquitin
ligase required for full Xa21-mediated disease resistance.
However, they contain a ubiquitin-interacting motif that weakly binds to ubiquitin
. (61) Furthermore, the UBL domain of Ddi family proteins exhibits an unconventional feature compared with ubiquitin
or other UBL proteins.
Fischer et al., "Alzheimer's associated variant ubiquitin
causes inhibition of the 26S proteasome and chaperone expression," Journal of Neurochemistry, vol.
The finger domains can interact with ubiquitin
to transfer its C-terminal to the cleft .
Geurink et al., "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin
chain restriction analysis," Cell, vol.
Yang, "Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin
ligase activity," Journal of Biological Chemistry, vol.
Similarly, UBE3A, which is another important molecule in the ubiquitin
system, was found to be associated with autistic symptoms in the Angelman syndrome (25,26).
The researchers said they also created ubiquitin
variant (UbVs) that blocks the Crimean-Congo virus, the cause of a haemorrhagic fever that kills about 40 per cent of those infected, Medical Xpress reported.
We hypothesized pCAF is playing a novel role as ubiquitin
E3 ligase for CIITA in addition to its traditional role as HAT.
Loss of Pin1 activity may increase the modification of ubiquitin
in PSD proteins and lead to the loss of Shank protein, resulting in aberrant PSD structure.
Although both variants share a common C-terminal ubiquitin
isopeptidase region, the structure of the Nterminal extension differs in terms of sequence, suggesting distinct roles in cellular processes [27-29].
NF-[kappa]B signaling is negatively regulated by USP11 or USP15-mediated removal of K48-linked ubiquitin
chains from I[kappa]B[alpha] [92, 93].