proteasome

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Related to Ubiquitin-proteasome system: Ubiquitin proteasome pathway, Immunoproteasome, E3 Ubiquitin Ligase

proteasome

[′prōd·ē·ə‚sōm]
(biochemistry)
A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins.
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References in periodicals archive ?
Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease.
Rutter, "Mitochondrial quality control by the ubiquitin-proteasome system," Biochemical Society Transactions, vol.
Impairment of the ubiquitin-proteasome system by protein aggregation.
Nearly seven percent of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system, making it the most complex of all biochemical pathways.
Neuronal cell adhesion molecules "are critical in the development of the nervous system, contributing to axonal guidance, synaptic formation and plasticity, and neuronal-glial interactions," the researchers explained, while the ubiquitin-proteasome system "operates pre- and post-synaptic compartments, regulating synaptic attributes, including transmitter release, synaptic vesicle recycling in pre-synaptic terminals, and dynamic changes in dendritic spines and the post-synaptic density.
Key words: 20S proteasome, dopamine system, neurotoxicology, oxidative stress, Parkinson disease, proteolytic stress, toxicodynamics, toxicokinetics, ubiquitin-proteasome system. Environ Health Perspect 115:1448-1453 (2007).
Gupta, the Ubiquitin-Proteasome system controls basic cellular processes such as cell division, cell signalling and gene regulation.
Intracellular proteinases, including calcium-activated proteinases and the ubiquitin-proteasome system, are also active at the time of molting and appear to be involved in controlling the molt-induced muscle atrophy (Mykles and Skinner, 1990; Mykles 1997, 1998).
Moreover, this Nrf2 inhibitor can also interact with Cul3-E3-ligase, which mediates Nrf2 degradation in ubiquitin-proteasome system. After that, the transcription function of Nrf2 is repressed [40] (Figure 2(a)).
Portoghese et al., "The ubiquitin-proteasome system contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control," Cardiovascular Pathology, vol.

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