Crosstalk and interplay between the ubiquitin-proteasome system
Relationship between amyloid-beta and the ubiquitin-proteasome system
in Alzheimer's disease.
Rutter, "Mitochondrial quality control by the ubiquitin-proteasome system
," Biochemical Society Transactions, vol.
Impairment of the ubiquitin-proteasome system
by protein aggregation.
Nearly seven percent of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system
, making it the most complex of all biochemical pathways.
The ubiquitin-proteasome system
and its role in ethanol-induced disorders.
Neuronal cell adhesion molecules "are critical in the development of the nervous system, contributing to axonal guidance, synaptic formation and plasticity, and neuronal-glial interactions," the researchers explained, while the ubiquitin-proteasome system
"operates pre- and post-synaptic compartments, regulating synaptic attributes, including transmitter release, synaptic vesicle recycling in pre-synaptic terminals, and dynamic changes in dendritic spines and the post-synaptic density.
Key words: 20S proteasome, dopamine system, neurotoxicology, oxidative stress, Parkinson disease, proteolytic stress, toxicodynamics, toxicokinetics, ubiquitin-proteasome system
. Environ Health Perspect 115:1448-1453 (2007).
Gupta, the Ubiquitin-Proteasome system
controls basic cellular processes such as cell division, cell signalling and gene regulation.
Intracellular proteinases, including calcium-activated proteinases and the ubiquitin-proteasome system
, are also active at the time of molting and appear to be involved in controlling the molt-induced muscle atrophy (Mykles and Skinner, 1990; Mykles 1997, 1998).
Moreover, this Nrf2 inhibitor can also interact with Cul3-E3-ligase, which mediates Nrf2 degradation in ubiquitin-proteasome system
. After that, the transcription function of Nrf2 is repressed  (Figure 2(a)).
Portoghese et al., "The ubiquitin-proteasome system
contributes to the inflammatory injury in ischemic diabetic myocardium: the role of glycemic control," Cardiovascular Pathology, vol.