uniporter


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uniporter

[′yü·nə‚pȯrd·ər]
(cell and molecular biology)
A channel protein that transfers only one substrate at a time across the membrane.
References in periodicals archive ?
It has been proposed that this mechanism involves a calcium-heavy metal uniporter uptake that transports divalent cations from the cytoplasm to the mitochondria, where an insoluble nontoxic precipitate is accumulated (Chavez-Crooker et al.
The plasma membrane Na[sup]+/Ca[sup]2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca[sup]2+ uniporter.
2+] loading, and this process can be blocked by ruthenium red, a mitochondrial calcium uniporter blocker [18].
They are also an important Ca2+ buffer, sequestering the ion through a uniporter that creates an electrochemical potential to pull the ion into the cell.
Moreover, most mammalian cells express GLUT1 uniporter transporter that transports blood glucose to fulfill cellular energy needs.
Using an "integrative genomics" strategy that included RNAi technology, the study identified for the first time the mitochondrial calcium uniporter (MCU), which regulates calcium transport into mitochondria.
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter," Nature Cell Biology, vol.
2+] uniporter, permeability transition pore (PTP), calcium-activated potassium channels ([formula not reproducible]), ATP-sensitive potassium channels ([K.
Parekh, "Mitochondrial calcium uniporter MCU supports cytoplasmic [Ca.
Rizzuto, "A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter," Nature, vol.
However, overexpression of miR-25 protected cardiomyocytes against oxidative damage by downregulating mitochondrial calcium uniporter (MCU) and enhanced cardiomyocyte activity [91].