uniporter


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uniporter

[′yü·nə‚pȯrd·ər]
(cell and molecular biology)
A channel protein that transfers only one substrate at a time across the membrane.
References in periodicals archive ?
Another point of interest is the effect of flavonoids on mitochondrial [Ca.sup.2+] uniporter within the cell, increasing mitochondrial [Ca.sup.2+] concentration.
Additionally, calcium ion could enter the mitochondrial matrix mediated by a calcium uniporter complex in a sodium calcium exchanger manner, which helps to alleviate calcium overload.
It has been proposed that this mechanism involves a calcium-heavy metal uniporter uptake that transports divalent cations from the cytoplasm to the mitochondria, where an insoluble nontoxic precipitate is accumulated (Chavez-Crooker et al.
The plasma membrane Na[sup]+/Ca[sup]2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca[sup]2+ uniporter. Br J Pharmacol 2007;151:647-54.
Zamparo et al., "The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo," Cell Reports, vol.
It is recently found that the [Ca.sup.2+] uptake into mitochondria is mediated by mitochondrial calcium uniporter (MCU), a unique ion channel with high conductance and selectivity [29].
They found this protein controls the channel (MCU, mitochondrial Calcium Uniporter) that allows calcium to enter mitochondria.
They are also an important Ca2+ buffer, sequestering the ion through a uniporter that creates an electrochemical potential to pull the ion into the cell.
Moreover, most mammalian cells express GLUT1 uniporter transporter that transports blood glucose to fulfill cellular energy needs.
2003), leading to the accumulation of [Ca.sup.2+] in mitochondria via the uptake by the inner membrane [Ca.sup.2+] uniporter (Gunter et al.
The mitochondrial electrogenic [Ca.sup.++] uniporter and [H.sup.+] ([Na.sup.+])/ [Ca.sup.++] antiporter (Pozzan et al., 1994), and plasma membrane [Na.sup.+]/[Ca.sup.++] antiporter (Missiaen et al., 1991; Thastrup, 1990) may also act to reduce intracellular free [Ca.sup.++] At still lowe r concentrations ([leq][10.sup.-5] to [approx][10.sup.-11] M [Ca.sup.++]), pigment dispersion ensues (Fig.