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blood,fluid pumped by the heart that circulates throughout the body via the arteries, veins, and capillaries (see circulatory systemcirculatory system,
group of organs that transport blood and the substances it carries to and from all parts of the body. The circulatory system can be considered as composed of two parts: the systemic circulation, which serves the body as a whole except for the lungs, and the
..... Click the link for more information. ; heartheart,
muscular organ that pumps blood to all parts of the body. The rhythmic beating of the heart is a ceaseless activity, lasting from before birth to the end of life. Anatomy and Function
The human heart is a pear-shaped structure about the size of a fist.
..... Click the link for more information. ). An adult male of average size normally has about 6 quarts (5.6 liters) of blood. The blood carries oxygen and nutrients to the body tissues and removes carbon dioxide and other wastes. The colorless fluid of the blood, or plasma, carries the red and white blood cells, platelets, waste products, and various other cells and substances.
Erythrocytes (Red Blood Cells)
The erythrocytes, or red blood cells, make up the largest population of blood cells, numbering from 4.5 million to 6 million per cubic millimeter of blood. They carry out the exchange of oxygen and carbon dioxide between the lungs and the body tissues. To effectively combine with oxygen, the erythrocytes must contain a normal amount of the red protein pigment hemoglobinhemoglobin
, respiratory protein found in the red blood cells (erythrocytes) of all vertebrates and some invertebrates. A hemoglobin molecule is composed of a protein group, known as globin, and four heme groups, each associated with an iron atom.
..... Click the link for more information. , the amount of which in turn depends on the iron level in the body. A deficiency of iron and therefore of hemoglobin leads to anemiaanemia
, condition in which the concentration of hemoglobin in the circulating blood is below normal. Such a condition is caused by a deficient number of erythrocytes (red blood cells), an abnormally low level of hemoglobin in the individual cells, or both these conditions
..... Click the link for more information. and poor oxygenation of the body tissues.
Erythrocytes are constantly developing from stem cells, the undifferentiated, self-regenerating cells that give rise to both erythrocytes and leukocytes in the bone marrowbone marrow,
soft tissue filling the spongy interiors of animal bones. Red marrow is the principal organ that forms blood cells in mammals, including humans (see blood). In children, the bones contain only red marrow.
..... Click the link for more information. . In the fetus, red blood cells are produced in the spleenspleen,
soft, purplish-red organ that lies under the diaphragm on the left side of the abdominal cavity. The spleen acts as a filter against foreign organisms that infect the bloodstream, and also filters out old red blood cells from the bloodstream and decomposes them.
..... Click the link for more information. . As they mature, the erythrocytes lose their nuclei, become disk-shaped, and begin to produce hemoglobin. After circulating for about 120 days, the erythrocytes wear out and undergo destruction by the spleen. Although all red blood cells are essentially similar, certain structures on their surfaces vary from person to person. These serve as the basis for the classification into blood groupsblood groups,
differentiation of blood by type, classified according to immunological (antigenic) properties, which are determined by specific substances on the surface of red blood cells.
..... Click the link for more information. . There are four major blood groups, whose compatibility or incompatibility is an important consideration in successful blood transfusionblood transfusion,
transfer of blood from one person to another, or from one animal to another of the same species. Transfusions are performed to replace a substantial loss of blood and as supportive treatment in certain diseases and blood disorders.
..... Click the link for more information. .
Leukocytes (White Blood Cells)
The leukocytes, or white blood cells, defend the body against infecting organisms and foreign agents, both in the tissues and in the bloodstream itself (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information. ). Human blood contains about 5,000 to 10,000 leukocytes per cubic millimeter; the number increases in the presence of infection. An extraordinary and prolonged proliferation of leukocytes is known as leukemialeukemia
, cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature leukocytes (white blood cells; see blood) and consequently a crowding-out of red blood cells and platelets.
..... Click the link for more information. . This overproduction suppresses the production of normal blood cells. Conversely, a sharp decrease in the number of leukocytes (leukopenia) strips the blood of its defense against infection and is an equally serious condition. A dramatic fall in levels of certain white blood cells occurs in persons with AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
..... Click the link for more information. . Leukocytes as well as erythrocytes are formed from stem cells in the bone marrow. They have nuclei and are classified into two groups: granulocytes and agranulocytes.
The granulocytes form in the bone marrow and account for about 70% of all white blood cells. Granulocytes include three types of cells: neutrophils, eosinophils, and basophils. Neutrophils constitute the vast majority of granulocytes. They travel about by ameboid movement and can surround and destroy bacteria and other foreign particles. The eosinophils, ordinarily about 2% of the granulocyte count, increase in number in the presence of allergic disorders and parasitic infestations. The basophils account for about 1% of the granulocytes. They release chemicals such as histamine and play a role in the inflammatory response to infection.
The agranulocytes include the monocytes and the lymphocytes. Monocytes are derived from the phagocytic cells that line many vascular and lymph channels, called the reticuloendothelial system. Monocytes ordinarily number 4% to 8% of the white cells. They move to areas of infection, where they are transformed into macrophages, large phagocytic cells that trap and destroy organisms left behind by the granulocytes and lymphocytes. In certain diseases of long duration (tuberculosistuberculosis
(TB), contagious, wasting disease caused by any of several mycobacteria. The most common form of the disease is tuberculosis of the lungs (pulmonary consumption, or phthisis), but the intestines, bones and joints, the skin, and the genitourinary, lymphatic, and
..... Click the link for more information. , malariamalaria,
infectious parasitic disease that can be either acute or chronic and is frequently recurrent. Malaria is common in Africa, Central and South America, the Mediterranean countries, Asia, and many of the Pacific islands.
..... Click the link for more information. , and typhoidtyphoid fever
acute, generalized infection caused by Salmonella typhi. The main sources of infection are contaminated water or milk and, especially in urban communities, food handlers who are carriers.
..... Click the link for more information. ) the monocytes act as the main instrument of defense.
Lymphocytes, under normal conditions, make up about 20% to 35% of all white cells, but proliferate rapidly in the face of infection. There are two basic types of lymphocytes: the B lymphocytes and the T lymphocytes. B lymphocytes tend to migrate into the connective tissue, where they develop into plasma cells that produce highly specific antibodies against foreign antigens. Other B lymphocytes act as memory cells, ready for subsequent infection by the same organism. Some T lymphocytes kill invading cells directly; others interact with other immune system cells, regulating the immune response.
Other Constituents of Blood
The blood also contains platelets, or thrombocytes, and at least 15 other factors active in blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
..... Click the link for more information. . Platelets are tiny plate-shaped cytoplasmic bags of blood-clotting chemicals produced by megakaryocytes; if their production is hindered, as by AIDS or chemotherapy, there is an increased risk of bleeding. Also circulating in the plasma are the hormones that the endocrine glands secrete directly into the bloodstream. In addition, essential salts (such as those of sodium and potassium), essential plasma proteins (albuminalbumin
[Lat.,=white of egg], member of a class of water-soluble, heat-coagulating proteins. Albumins are widely distributed in plant and animal tissues, e.g., ovalbumin of egg, myogen of muscle, serum albumin of blood, lactalbumin of milk, legumelin of peas, and leucosin of
..... Click the link for more information. , globulinsglobulin,
any of a large family of proteins of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form.
..... Click the link for more information. , and fibrinogen), and metabolic wastes (such as ureaurea
, organic compound that is the principal end product of nitrogen metabolism in most mammals. Urea was the first animal metabolite to be isolated in crystalline form; its crystallization was described in the early 18th cent.
..... Click the link for more information. ) circulate in the plasma.
Serum, a straw-colored liquid, essentially composed of plasma without fibrinogen, makes up the liquid component of blood that separates from the clot. Serum is separated from whole blood by centrifuging and can serve various medical uses. Normal human serum is sometimes used to treat shock and the loss of fluid resulting from severe burns.
See D. Starr, Blood (1998).
The fluid that circulates in the blood vessels of the body. Blood consists of plasma and cells floating within it. The cells are derived from extravascular sites and then enter the circulatory system. They frequently leave the blood vessels to enter the extravascular spaces, where some of them may be transformed into connective tissue cells. The fluid part of the blood is in equilibrium with the tissue fluids of the body. The circulating blood carries nutrients and oxygen to the body cells, and is thus an important means of maintaining the homeostasis of the body. It carries hormones from their sites of origin throughout the body, and is thus the transmitter of the chemical integrators of the body. Blood plasma also circulates immune bodies and contains several of the components essential for the formation of blood clots. Finally, blood transports waste products to excretory organs for elimination from the body. Because of its basic composition (cells surrounded by a matrix), development, and ability to modify into other forms of connective tissues, blood can be regarded as a special form of connective tissue. See Connective tissue
The cells of the blood include the red blood cells and the white blood cells. In all vertebrates, except nearly all mammals, the red blood cells or corpuscles contain a nucleus and cytoplasm rich in hemoglobin. In nearly all mammals the nucleus has been extruded during the developmental stages.
In normal adult men the blood contains about 5,000,000 red blood corpuscles or erythrocytes per cubic millimeter; in normal adult women, about 4,500,000. Human erythrocytes are about 8 micrometers in diameter and about 2 μm at their thickest and have a biconcave shape. They contain hemoglobin, which imparts to them their color, and possess an envelope. When circulating in the blood vessels, the red blood cells are not evenly dispersed. In the capillaries the erythrocytes are often distorted. In certain conditions they may be densely aggregated. This is known as a sludge. The erythrocytes respond to changes in osmotic pressure of the surrounding fluid by swelling in hypotonic fluids and by shrinking irregularly in hypertonic fluids. Shrunken red blood cells are referred to as crenated cells. The average life of the mature red blood cells is surprisingly long, having a span of about 120 days. See Hemoglobin
In humans the white blood cells in the blood are fewer in number. There are about 5000–9000/mm3. In general, there are two varieties, agranular and granular. The agranular cells include the small, medium, and large lymphocytes and the monocytes (see illustration). The small lymphocytes are spherical, about the diameter of erythrocytes or a little larger, and constitute about 20–25% of the white blood cells. The medium and large lymphocytes are relatively scarce. In all lymphocytes the nucleus occupies nearly the whole volume of the cell, and the cytoplasm which surrounds it forms a thin shell. The typical monocyte is commonly as large as a large lymphocyte (12 μm), and constitutes 3–8% of the white blood cells. The nucleus is relatively small, eccentric, and oval or kidney-shaped. The cytoplasm is relatively larger in volume than that in lymphocytes.
The granular leukocytes are of three varieties: neutrophil, eosinophil, and basophil. Their structure varies somewhat in different species, and the following applies to those of humans. The neutrophils make up 65–75% of the leukocytes. They are about as large as monocytes with a highly variable nucleus, consisting of three to five lobes joined together by threads of chromatin. The cytoplasm contains numerous minute granules which stain with neutral dyes and eosin. The eosinophils (also called acidophils) are about the same size as the neutrophils but are less numerous, constituting about 1% of the leukocytes. The nucleus commonly contains but two lobes joined by a thin thread of chromatin. The granules which fill the cytoplasm are larger than those of the neutrophils and stain with acid dyes. The basophils are about the same size as the other granular leukocytes. The nucleus may appear elongated or with one or more constrictions. The granules are moderately large, stain with basic dyes, and are water-soluble.
The functions of the leukocytes while they are circulating in the blood are not known. However, when they leave the blood vessels and enter the connective tissue, they constitute an important part of the defense mechanism and of the repair mechanism. Many of the cells are actively phagocytic and engulf debris and bacteria. Lymphocytes are of two major kinds, T cells and B cells. They are involved in the formation of antibodies and in cellular immunity.
The blood platelets are small spindle-shaped or rodlike bodies about 3 μm long and occur in large numbers in circulating blood. In suitably stained specimens they consist of a granular central portion (chromomere) embedded in a homogeneous matrix (hyalomere). They change their shape rapidly on contact with injured vessels or foreign surfaces and take part in clot formation. The platelets are not to be regarded as cells and are thought to be cytoplasmic bits broken off from their cells of origin in bone marrow, the megakaryocytes.
Plasma is the residual fluid of blood left after removal of the cellular elements. Serum is the fluid which is obtained after blood has been allowed to clot and the clot has been removed. Serum and plasma differ only in their content of fibrinogen and several minor components which are in large part removed in the clotting process. See Serum
The major constituents of plasma and serum are proteins. The total protein concentration of human serum is approximately 7 g/ml, and most other mammals show similar levels. By various methods it can be demonstrated that serum protein is a heterogeneous mixture of a large number of constituents. Only a few are present in higher concentrations, the majority being present in trace amounts. More than 60 protein components have been identified and characterized. Albumin makes up more than one-half of the total plasma proteins and has a molecular weight of 69,000. Because of its relatively small molecular size and its high concentration, albumin contributes to 75–80% of the colloid osmotic pressure of plasma. The immunoglobulins, which represent approximately one-sixth of the total protein, largely constitute the γ-globulin fraction. The immunoglobulins are antibodies circulating in the blood, and therefore are also called humoral antibodies. They are of great importance in the organism's defense against infectious agents, as well as other foreign substances. See Immunoglobulin
In addition to the proteins, many other important classes of compounds circulate in the blood plasma. Most of these are smaller molecules which diffuse freely through cell membranes and are, therefore, more similarly distributed throughout all the fluids of the body and not as characteristic for plasma or serum as the proteins. In terms of their concentration and their function, the electrolytes are most important. They are the primary factors in the regulation of the osmotic pressure of plasma, and contribute also to the control of the pH. The chief cations are sodium, potassium, calcium, and magnesium. The chief anions are chloride, bicarbonate, phosphate, sulfate, and organic acids. The circulating blood also contains the many small compounds which are transported to the sites of synthesis of larger molecules in which they are incorporated, or which are shifted as products of metabolic breakdown to the sites of their excretion from the body.
When mammalian blood is shed, it congeals rapidly into a gelatinous clot of enmeshed fibrin threads which trap blood cells and serum. Modern theories envision a succession of reactions leading to the formation of insoluble fibrin from a soluble precursor, fibrinogen (factor I). Blood also clots when it touches glass or other negatively charged surfaces, through reactions described as the intrinsic pathway. Several of the steps in this process are dependent upon the presence in blood of calcium ions and of phospholipids, the latter derived principally from blood platelets. The coagulation of blood can also be induced by certain snake venoms which either promote the formation of thrombin or clot fibrinogen directly, accounting in part for their toxicity.
Platelets, besides furnishing phospholipids for the clotting process, help to stanch the flow of blood from injured blood vessels by accumulating at the point of injury, forming a plug. Platelets participate in the phenomenon of clot retraction, in which the blood clot shrinks, expelling liquid serum. Although the function of retraction is unknown, individuals in whom this process is impaired have a bleeding tendency.
Hereditary deficiencies of the function of each of the protein-clotting factors have been described, notably classic hemophilia and Christmas disease, which are disorders of males and clinically indistinguishable. The various hereditary functional deficiencies are associated with a bleeding tendency with one inexplicable exception. Acquired deficiencies of clotting factors, sometimes of great complexity, are also recognized. Therapy for bleeding due to deficiencies of clotting factors often includes the transfusion of blood plasma or fractions of plasma rich in particular substances the patient may lack. See Human genetics
Clinical tests of the coagulability of the blood include (1) determination of the clotting time, that is, the time elapsing until shed blood clots; (2) the prothrombin time, the time elapsing until plasma clots in the presence of tissue thromboplastin (and therefore a measure of the extrinsic pathway of clotting); (3) the partial thromboplastin time, the time elapsing until plasma clots in the presence of crude phospholipid (and therefore a measure of the intrinsic pathway of clotting); (4) the enumeration of platelets; and (5) crude quantification of clot retraction and of the various plasma protein-clotting factors.
Heparin, a polysaccharide–sulfuric acid complex found particularly in the liver and lungs, impairs coagulation; its presence in normal blood is disputed. Both coumarin and heparin are used clinically to impede coagulation in thrombotic states, including thrombophlebitis and coronary heart disease. See Fibrinogen
Blood Symbolism among the Ancient Jews
The Hebrew scriptures known to Christians as the Old Testament teach that a creature's life force is contained in its blood (Leviticus 17:11). This belief turned blood into both a powerful symbol and a source of potential physical and spiritual contamination. The association of blood with violence and death may have inspired belief in the power of blood to contaminate.
The power of blood could be turned to good purposes, however. Jewish scripture relates several important instances where blood was used to seal a covenant, or agreement, between God and his faithful people. For example, the Book of Exodus recounts how Jewish families enslaved in Egypt obeyed the Lord's command, relayed to them by the prophet Moses, to sacrifice a lamb to God and smear its blood over their doorways. God used this mark to identify which homes to pass over when wreaking vengeance on the Egyptians for their cruelty and disobedience. Jews still commemorate these events in the yearly Passover festival. After the Jews escaped from Egypt Moses informed them of God's new rules for them. Then Moses signified the Jews' agreement to this plan by scattering the blood of sacrificed bulls on the people and the altar (Exodus 24:3-8).
The ancient Jews also sacrificed animals to God on other occasions. They made these sacrifices for a number of reasons, including as a way of showing reverence, offering thanks, and asking for reconciliation with God. The Bible sometimes refers to this process of reconciliation as redemption. A passage from Hebrew scripture explains the role of blood offerings in gaining God's forgiveness. In the book of the Bible called Leviticus, God informs the Jews that ". . . the life of the flesh is in the blood, and I have given it for you upon the altar to make atonement for your souls: for it is the blood that makes atonement, by reason of the life" (Leviticus 17:11). Animal sacrifices entailed sprinkling the blood of the slain animals on the altar. This blood represented the life force of the animal, and so some scholars believe that in the context of the sacrifice it served as a symbolic substitute for the life force of the person or group making the sacrifice. Thus in offering the blood of slain animals to God, faithful Jews of this period were symbolically offering their own lives to God. Other researchers contend that the ancient Jews believed that their sins dirtied the temple and that sacrifices could restore the house of God to a state of purity.
Blood Symbolism among the First Christians
Although the Christian religion grew out of Judaism, it did not recreate the ancient Jewish custom of animal sacrifice. Instead Christians grew to understand Jesus'death as a one-time-only sacrifice on behalf of all his followers and the world. Nevertheless, Christians interpreted Jesus'sacrifice in terms of the blood symbolism already established in Jewish religious culture. Jesus himself instructed them to do so.
On the night before Jesus died he shared a meal with his twelve disciples (see also Maundy Thursday). During this meal he passed bread and wine to his followers, telling them that the wine represented his blood and the bread his body. In Matthew's version of the story Jesus not only identifies the wine as his blood, but also as "the blood of the covenant, which is poured out for many for the forgiveness of sins" (Matthew 26:28). Jesus, aware that he will soon die, is interpreting his own death for his followers. He describes it as a blood sacrifice which will establish a new covenant, or relationship, between God and humanity. Moreover, just as the blood of a sacrificial animal could confer the forgiveness of sins, Jesus' blood - freely offered on behalf of all his followers - will cleanse them of their sins. Jesus' blood thereby became the vehicle which reconciles his followers with God, that is to say, re-establishes good will and harmony between them.
Christian scripture records that Jesus indeed suffered a bloody death on the cross the following day. Christians commemorate this terrible event each year on Good Friday. They also honor Jesus' words and deeds at the Last Supper with the Eucharist, celebrated every Sunday in many churches. This rite offers worshipers the opportunity to share in the soul-sustaining consequences of Jesus'sacrificial death. According to the Gospel of John, partaking of Jesus' body and blood imparts eternal life and a mystical connection to Christ (John 6:5456). This doctrine builds on the ancient Hebrew belief that the life force of all creatures resides in their blood. Therefore, by consuming Jesus' blood, his followers absorb some part of Jesus' divine nature and his connection to God. Regular participation in this ceremony strengthens their spiritual bond with Christ. This ritual sheds additional light on the meaning of Jesus' death, implying that Jesus sacrificed his own life so that others could share in it (see also Salvation).
"Blood." In Leland Ryken, James C. Wilhoit, and Tremper Longman III, eds. Dictionary of Biblical Imagery. Downers Grove, IL: InterVarsity Press, 1998. Mason, Steve A. "Sacrifices and Offerings." In David Noel Freedman, ed. Eerdmans Dictionary of the Bible. Grand Rapids, MI: William B. Eerdmans Publishing, 2000. Potts, Donald R. "Blood." In David Noel Freedman, ed. Eerdmans Dictionary of the Bible. Grand Rapids, MI: William B. Eerdmans Publishing, 2000. Roux, Jean-Paul. "Blood." In Mircea Elide, ed. The Encyclopedia of Religion. Volume 12. New York: Macmillan, 1987. "Sacrifice." In Leland Ryken, James C. Wilhoit, and Tremper Longman III, eds. Dictionary of Biblical Imagery. Downers Grove, IL: InterVarsity Press, 1998.
Blood(religion, spiritualism, and occult)
Blood appears in Act I, Scene V, of Henry VI Part One—ascribed to Shakespeare but generally attributed to as many as four additional authors: Peele, Marlow, Lodge, and Nash, with only slight input from Shakespeare himself. (It should be borne of mind, of course, that some evidence seems to point to Edward de Vere, Seventeenth Earl of Oxford, as being the true author of "Shakespeare's" works.) Lord Talbot addresses Joan La Pucelle (Joan of Arc) with the words: I'll have a bout with thee; Devil or Devil's dam, I'll conjure thee: Blood will I draw from thee, thou art a witch, And straightway give thy soul to him thou servest.
This echoed the idea that to "blood" a witch was to take away her powers. Another expression, "to score above the breath," meant to blood the witch about the head, which was thought to be especially effective.
Blood is seen not only as the life force of humankind but also as the source of magical power. In Wiccan traditions, there is a ritual scourging, which is part of the building of "power" for magical work. According to the Gardnerian Book of Shadows, the Scourge is used "to bring blood to the surface of the skin; not to hurt." Dancing, prior to working magic, is another way to get the blood coursing through the veins, according to Wiccans.
In Wiccan Initiations there is another use for blood. In many traditions a "measure" is taken. This is a length of thread which is used to measure certain parts of the Initiate's body. The thread is then rolled into a ball and daubed with a drop of the Initiate's blood (obtained with a pin-prick to the end of a finger). This "measure" is then held by the coven leader(s), ostensibly to ensure that the coven secrets are not divulged. As a form of imitative magic, the measure represents the new Witch, so that anything done to the measure would affect the Witch.
In similar fashion, a drop of blood can serve as a "witness" for magical work; it represents the person from whom it comes and, therefore, anything done to it will affect that person. It may be worked into a wax poppet or smeared onto a piece of paper. In Wicca, this may be used to work healing magic at a distance, when the actual person cannot be present.
It was believed that "witch blood" ran in families—that the children of witches would automatically become witches themselves. For this reason children of witches were invariably put to death along with their parent(s). In Salem, Massachusetts,
chalcedony with crimson spots, while true bloodstone is a green jasper flecked with red. In gem therapy, bloodstone is considered excellent for stopping bleeding.
Bloodstone is also known as haematite. Powder scraped from the stone is believed to help in the stanching of blood and is thought to aid women in childbirth. It is also used for bloodshot eyes, for snake bite, and is considered a protection against the evil eye. The name "bloodstone" is also applied to red agate, red coral, red jasper, red marble, and carnelian.
Nothing has so defined the vampire as its relationship to blood. The vampire was essentially a bloodsucker, a creature who lived off of the blood of humans. Quite early in his visit to Castle Dracula, Jonathan Harker was lectured by his host on the general importance of blood. He noted that the Szekelys, “we of the Dracula blood,” helped to throw off the despised Hungarian yoke. He further noted, in a line which soon would take on a double meaning, “Blood is too precious a thing in these days of dishonorable peace …” (chapter 3). As Harker tried to understand his desperate situation, he noted that Dracula had bad breath with “a bitter offensiveness, as one smells in blood.” He discovered the secret when he found Dracula asleep with his mouth redder than ever and “on the lips were gouts of fresh blood, which trickled from the corners of the mouth and ran over the chin and neck…. It seemed as if the whole awful creature were simply gorged with blood; he lay like a filthy leech, exhausted with his repletion.” Harker lamented his role in freeing Dracula on London.
The Significance of Blood: Since ancient times, humans have seen the connection between blood and life. Women made the connection between birth and their menstrual flow. Hunters observed the relationship between the spilling of blood and the subsequent loss of consciousness, the ceasing of breath, and eventual death of the animals they sought. And if an animal died of some cause with no outward wound, when cut, the blood often did not flow. Blood was identified with life, and thinkers through the ages produced endless speculations about that connection. People assigned various sacred and magical qualities to blood and used it in a variety of rituals. People drank it, rubbed it on their bodies, and manipulated it in ceremonies.
Some believed that by drinking the blood of a victim the conqueror absorbed the additional strength of the conquered. By drinking the blood of an animal one took on its qualities. As late as the seventeenth century, the women of the Yorkshire area of England were reported to believe that by drinking the blood of their enemies they could increase their fecundity.
Among blood’s more noticeable qualities was its red color as it flowed out of the body, and as a result redness came to be seen as an essential characteristic of blood, the vehicle of its power. Red objects were often endowed with the same potency as blood. In particular, red wine was identified with blood, and in ancient Greece, for example, red wine was drunk by the devotees of the god Dionysus in a symbolic ritual drinking of his blood.
Blood was (and continues to be) seen as somehow related to the qualities possessed by an individual, and beliefs carried references to admirable people as having “good” blood or evil persons as possessing “bad” blood. The blood of the mother was passed to the child, and with it the virtues and defects of the parents were passed to any offspring. Thus blood, in a somewhat literal sense, carried the essential characteristics of the larger collectives—families, clans, national/ethnic groups, even whole races. Such beliefs underlie the modern myth that permitted the Nazi purge of Jews and other supposed lesser races and the practices in American blood banks until recent decades to separate “Negro” blood from that of “white” people.
To a lesser extent, blood was identified with other body fluids, most notably semen. In the process of creating a baby, men do not supply blood, only their seed. Thus it was through the semen that male characteristics were passed to the child. In the mythology of race, each of the body fluids—semen, the blood that flowed when the hymen was broken, and menstrual blood—were associated together as part of sexual life and ascribed magical properties. This association was quite explicit in the sexual teaching of modern ritual magic.
Blood in the Biblical Tradition: The ancient Jewish leaders made the same identification of blood and life. In the biblical book of Genesis, God tells Noah:
But you must not eat the flesh with the life, which is the blood, still in it. And further, for your life-blood I will demand satisfaction; from every animal will I require it, and from a man also will require satisfaction for the death of his fellow-man.
He that shed the blood of a man, for that man his blood shall be shed; for in the image of God has God made man.
Israel instituted a system of blood sacrifice in which animal blood was shed as an offering to God for the sins of the people. The book of Leviticus included detailed rules for such offerings with special attention given to the proper priestly actions to be taken with the blood. The very first chapter stated the simple rules for offering a bull. It was to be slaughtered before the Tent of the Presence, and the priest was to present the blood and then fling it against the altar. The mysterious sacredness of the blood was emphasized in that God reserved it to himself. The remaining blood was spilled before the altar, and strictures were announced against the people eating the blood. “Every person who eats the blood shall be cut off from his father’s kin” (Lev 7:27).
Special rules were also established for women concerning their menstrual flow and the flow of blood that accompanied childbirth. Both made a woman ritually impure, and purification rituals had to be performed before she could again enter a sanctuary. In like measure, the discharge of semen caused a man to be ritually impure.
The most stringent rules concerning blood were in that section of Leviticus called the Holiness Code, a special set of rules stressing the role of the people, as opposed to the priest, in being holy before God. Very early in the code, the people are told:
If any Israelite or alien settled in Israel eats blood, I will see my face against the eater; and cut him off from his people, because the life of a creature is the blood, and I appoint it to make expiation on the altar for yourselves; for the blood is the life that makes expiation. Therefore I have told the Israelites that neither you, nor any alien settled among you, shall eat blood.
Indeed, “For the blood is the life” has been the most quoted Biblical phrase in the vampire literature.
Christianity took Jewish belief and practice to its extreme and logical conclusion. Following his death and (as Christians believe) his resurrection, Jesus, its founder, was worshiped as an incarnation of God who died at the hands of Roman executioners. Christians depicted his death as a human sacrifice, analogous, yet far more powerful, than the Jewish animal sacrifices. As the accounts of his last days relate Jesus instituted the Lord’s Supper during which he took a cup of wine and told his disciples, “Drink from it, all of you. For this is my blood, the blood of the covenant, shed for many for the forgiveness of sins” (Matthew 26:27). Following his sentencing of Jesus, the Roman governor Pilate washed his hands and told the crowd who had demanded Jesus’s death, “My hands are clean of this man’s blood.” The crowd replied, “His blood be upon us, and on our children” (Matthew 27:24–26). As he hung on the cross, a soldier pierced his side with a lance, and his blood flowed from the wound.
Early Christian thought on the significance of Christ’s death was clearly presented in the Apocalypse (The Book of Revelation) in which John spoke of Jesus as the one who “freed us from our sins with his life’s blood” (Revelation 1:5). He admonished those suffering persecution by picturing their glory in heaven as the martyrs for the faith. They wore a white robe which had been washed in the blood of the Lamb.
In Christian lands, to the common wisdom concerning life and blood, theological reflection added a special importance to blood. The blood of Christ, in the form of the red wine of the Eucharist, became the most sacred of objects. So holy had the wine become that during the Middle Ages a great controversy arose over allowing the laity to have the cup. Because of possible carelessness with the wine, the Roman Catholic Church denied the cup, a practice which added more fuel to the fire of the Protestant Reformation of the sixteenth century.
In the light of the special sacredness of Christ’s blood, the vampire, at least in its European appearances, took on added significance. The vampire drank blood in direct defiance of the biblical command. It defiled the holy and stole that which was reserved for God alone.
The Vampire and Hematology: The vampire myth arose, of course, prior to modern medicine. It has been of some interest that Dracula was written just as modern medicine was emerging, and Bram Stoker mixed traditional lore about blood with the new medicine. Lucy Westenra, even as she anticipated her marriage to Arthur Holmwood, lay hovering near death. Reacting quickly, Abraham Van Helsing gathered Holmwood and Lucy’s two other suitors, Quincey P. Morris and Dr. John Seward, to apply a wholly unique scientific remedy to the vampire’s attack. He had diagnosed a loss of blood, and now Van Helsing ordered a transfusion, at the time a new medical option. He and each of Lucy’s suitors in turn gave her their blood. Following her death, Holmwood, in his grief and disappointment, made the observation that in the giving of blood he had in fact married Lucy and that in the sight of God they were husband and wife. Van Helsing, assuming his scientific role, countered his idea by suggesting that such an observation would make Lucy a polyandrist and the previously married Van Helsing a bigamist.
The idea of using a transfusion to counter the vampire introduced a new concern into the developing myth of the vampire through the twentieth century, especially as the supernatural elements of the myth were being discarded. If vampirism was not a supernatural state, and rather was caused ultimately by a moral or theological flaw of the original vampires, then possibly the blood thirst was the symptom of a diseased condition, caused by a germ or a chemical disorder of the blood, either of which might be passed by the vampire’s bite. In the mid-1960s there was brief, yet serious, medical speculation that vampirism was the result of misdiagnosed porphyria, a disease that causes its victims to be sensitive to sunlight and which could be cured or helped.
Anemia is a disease of the blood that was initially associated with vampirism. Anemia is caused by a reduction of either red blood cells or hemoglobin (the oxygen-carrying pigment of the cells) relative to the other ingredients in the blood. The symptoms include a pale complexion, fatigue, and in its more extreme instances, fainting spells. All are symptoms usually associated with a vampire attack. In Bram Stoker’s novel, Dracula, during the early stages of Lucy Westenra’s illness, Dr. John Seward hypothesized that possibly she was suffering from anemia. He later concluded that she was not suffering from the loss of red blood cells, but from the loss of whole blood. Dr. Abraham Van Helsing agreed with his friend: “I have made careful examination, but there is no functional cause. With you I agree that there has been much blood lost; it has been, but is not. But the conditions of her are in no way anaemic” (chapter 9). While Stoker dismissed any association of anemia and vampirism, over the succeeding decades, attempts to posit anemia as the underlying explanation of vampirism occasionally emerged.
The Literary Tradition: Increasingly through the century, as knowledge of the minute details concerning the function and makeup of human blood were explored by research specialists, novelists and screenwriters toyed with the idea of vampirism as a disease. During the last years of the pulp fiction era, writers such as Robert Bloch, George Whitley, David H. Keller, and William Tenn suggested the diseased origin of vampirism in a series of short stories. For example, in William Tenn’s 1956 short story “She Only Goes Out at Night,” Tom Judd, the son of a village doctor, falls in love with a strange woman. Tom’s father coincidentally discovers an epidemic in town whose victims are all anemic. The woman, who has just moved to town, is a Romanian by descent and only comes out at night. Putting the sudden wave of anemia together with the behavior patterns of the woman, the wise old doctor suggests she is a vampire. As he explains it, the vampire condition is passed from parent to child, though usually only one child in each generation develops it. His son still wants to marry the woman. He responds with a medical observation, “Vampirism may have been an incurable disease in the fifteenth century, but I am sure it can be handled in the twentieth.” Her symptoms suggests she has an allergy to the sun, for which he prescribes sunglasses and hormone injections. He then deals with her blood thirst by supplying her with dehydrated crystalline blood which she mixes with water and drinks once a day. The vampire and Tom live happily ever after.
Vampirism as disease came powerfully to the fore in the late 1960s television series Dark Shadows. Dr. Julia Hoffman was introduced into the show to treat the problems of Maggie Evans, one of the show’s main characters. A short time after her initial appearance, she meets Barnabas Collins and discovers that he is a vampire. Rather than seek to destroy him, however, she devises a plan to assist him in a cure of his vampiric condition. Collins soon grows impatient and demands that the process be speeded up. His body does not react favorably to the increased dosages of Hoffman’s medicines, and he reverts to his true age—two hundred years old. He is able to revive his youth by biting a young woman, and he then turns on Hoffman. Hoffman is able to thwart his efforts by threatening him with her research book, which contains all the details of her treatments and reveals Collins’s true nature. Before Collins can locate the book, he and the storyline are transported into the past, to 1795.
Shortly after his return to the present (1968), Collins is in a car accident. Hospitalized, he receives a transfusion that temporarily cures him. He is a human and, for the first time in two hundred years, is able to walk in the sunlight. He is, however, returned to his vampiric state by the bite of his former love, Angelique Bouchard, who has died and returned as a vampire.
A character similar to Hoffman also appeared in the recent television series, Forever Knight. Nicolas Knight, the show’s vampire, is a policeman on the Toronto police force. His friend and confidante is Dr. Natalie Lambert, a forensic pathologist. Throughout the series, she seeks a means to transform Knight into a human, but with negative results. In the decades since World War II, novelists have also explored the idea that a diseased condition produced vampirism. Simon Raven’s Doctors Wear Scarlet (1960), for example, described vampirism as a form of “sado-sexual perversion.” The story sent the hero, Richard Fountain, to Greece to escape an oppressive personal situation in England. In Greece he meets a beautiful vampiress who slowly drains his blood. He is rescued before he is killed and returns safe to his British home.
Jan Jennings’s Vampyr (1981) brings a research scientist into a relationship with Valan Anderwalt, a vampiress. The scientist, in love with Valan, tries to find the causes of her state. He traces vampirism to ancient China and finds it to be a contagious physical condition which had been brought to America by the early Dutch colonists. Unfortunately, he is not able to make any progress in curing her.
That same year Whitley Strieber introduced an interesting triangle relationship in The Hunger. Miriam Blaylock is an immortal alien vampire. She is on earth and can transform humans into vampires. Such human vampires, however, are not immortal and begin to age and disintegrate after several centuries pass. Not wishing to lose another companion, Blaylock seeks out the services of an expert in longevity, Sarah Roberts, in the hopes that she will be able to save John, her present male companion. Unfortunately, no solution presents itself before John succumbs to his deteriorating condition. Most recently, Dan Simmons sent his leading character, Kate Neuman, a hematologist, into post-revolutionary Romania in Children of the Night. The book begins with her using her knowledge of rare blood diseases to treat people in Bucharest. While there, she falls in love with a seven-month-old boy, Joshua, presumably an orphan. He is unique in that he requires biweekly transfusions to stay alive. He also has unusual blood which, she comes to believe, holds the clue to cures for AIDS, cancer, and other blood diseases. She arranges his adoption and brings him home with her to Colorado. Soon after, the boy is kidnapped and returned to Romania. In the exciting climax of the story, she is forced to return to Romania and face the boy’s father, Vlad the Impaler, the real Dracula. Because Dracula was dying, his son, Joshua, was to become the leader of the family in his place.
Conclusion: The traditional beliefs that surrounded blood, the medical exploration of its properties, and the analogies it harbored to life itself, facilitated the adaptability of the vampire myth to a seemingly endless number of situations. Such adaptability has provided an understanding of why the vampire myth has stayed alive and has so many devotees to this day. Scientific considerations of the vital function played by blood in the human body have, if anything, given it an even more mystical place in human life and promoted the belief in its sacredness in this post-secular society.
Since the early 1990s, blood and related body fluids have been very much in the news around such subjects as AIDS, the analysis of blood in criminal investigations, and genetic research around DNA. Interestingly, little has been done by vampire writers to exploit these burgeoning fields in the equally expanding field of vampire fiction.
Blood Drinking see: Crime, Vampiric
a fluid tissue that moves through the circulatory system of man and animals, providing for vital activities and the performance of various physiological functions of the body’s cells and tissues.
Overview. One of the principal functions of the blood is the transport of gases (O2 from the respiratory organs to the tissues and CO2 from the tissues to the respiratory organs). Blood is also involved in the transfer of glucose, amino acids, fatty acids, salts, and other nutrients from the digestive organs to the tissues. In addition, it carries the end products of metabolism, such as urea, uric acid, and creatinine, to the excretory organs. Blood takes part in the regulation of the body’s water-salt metabolism and acid-base equilibrium and plays an important role in maintaining constant body temperature. A protective function is carried out by the antibodies, antitoxins, and lysines present in the blood and by the white blood cells, or leukocytes, which are capable of absorbing microorganisms and foreign bodies. A very important protective adaptation, one that prevents blood loss from the body, is the arrest of blood flow as a result of coagulation.
Blood contains a number of chemical compounds for which the demand changes with the functional activities of the tissues. However, the blood’s chemical composition, the active reaction of its medium (pH), and other physical and chemical constants maintain relative stability. This is ensured by the mechanisms of homeostasis, which include the blood’s rate of flow (regulating the entry of nutrient substances into the tissues), the capacity of the excretory organs to remove metabolic products, and the maintenance of the water balance (achieved by the exchange of fluid between the blood and the lymph). Homeostasis is also maintained by regulation of the metabolism (matter and energy) of biologically active substances (histamine, serotonin, acetylcholine) and by hormones transported by the blood from site of formation to site of activity.
In unicellular organisms and in many invertebrates (protozoans, sponges, coelenterates), oxygen is supplied by means of diffusion from the external environment through the body surface. In some primitive metazoans there is a system of canals communicating with the external environment (the gastrovascular system) through which hydrolymph circulates. Hydrolymph delivers nutrients to the cells and removes their metabolic products, but it does not, as a rule, bind and transport oxygen. Only in a few invertebrates does the hydrolymph contain protein pigments that are capable of carrying oxygen. In more developed animals (mollusks and arthropods) there is an open system of blood circulation, filled with hemolymph and communicating with the intertissular spaces. In a number of invertebrates, all vertebrates, and man, the circulatory system is closed and the blood is separated from the interstitial fluid and lymph.
Only in a few relatively inactive animals is blood (or hemolymph) able to carry sufficient oxygen in a dissolved state without the participation of respiratory pigments (chromoproteins). With the appearance at a certain stage of animal evolution of respiratory pigments, the ability of the blood to bind oxygen and to release it to the tissues increases sharply. These pigments include hemoglobin, chlorocruorin, and hemerythrin, which contain iron in the nonprotein parts of their molecules, and hemocyanin, which contains copper. The pigments are either dissolved in hemolymph or carried in blood corpuscles. The green pigment chlorocruorin is dissolved in the plasma of polychaetes. Hemerythrin, a violet pigment, is contained in the blood corpuscles of polychaetes, sipunculids, and brachiopods. The blood of many mollusks and coelenterates is blue because of the hemocyanin dissolved in it. Hemoglobin is the most widely distributed. This red pigment is dissolved in the perivisceral fluid or blood of many invertebrates, and it is found in the erythrocytes of all vertebrates, including man.
In invertebrates the ratio of the mass of the fluid that performs the function of blood to the mass of the body is significantly higher than in vertebrates. Whereas hemolymph constitutes 30 percent of the mass of the mollusk Anodonta and 20 percent in many insects, blood constitutes only 2–8 percent of the body mass in vertebrates (in fish, about 3 percent; in amphibians, to 6 percent; in reptiles, 6.5 percent; and in birds and mammals, to 8 percent). Blood averages 6.8 percent of the body weight in man (about 5 liters for a weight of 70 kg). The decrease in the relative volume of the blood in vertebrates may be explained by the development of the closed system of blood circulation and the appearance of respiratory pigments that effectively bind oxygen.
In vertebrates, the blood is a thick, homogeneous, red fluid that consists of a liquid part, or plasma, and formed elements— the erythrocytes, which give blood its red color, the leukocytes, and the thrombocytes, or blood platelets. The volume of formed elements in the lower vertebrates (fish, amphibians, and reptiles) is 15–40 percent. In higher vertebrates (birds and mammals) it is 35–54 percent. Of the formed elements, the erythrocytes are the most numerous. Their number and size differ for different vertebrates. Thus, among the ungulates, 1 cu mm of llama blood contains 15.4 million erythrocytes, and 1 cu mm of goat blood contains 13 million; in the reptiles, the range is from 500,000 to 1.65 million; and among the chondrosteans, from 90,000 to 130,000. The smallest erythrocytes are found in mammals; in the musk deer, the diameter is about 2.5 microns (μm) and in the goat, about 4.0 μm. The largest erythrocytes are found in amphibians (70 μm, in the urodele Amphiumd).
The erythrocytes in all vertebrates except the mammals are elliptical and have a nucleus. In mammals the erythrocytes are nonnucleated and are shaped like biconcave disks (with the exception of the camel, in which the erythrocytes are oval and lentiform). Increasing the number of erythrocytes and decreasing their size improves the oxygen supply to the body. In the lower vertebrates, 100 ml of blood contains 5–10 g of hemoglobin; in fish, 6–11 g; and in the mammals, 10–15 g. In man, 1 cu mm of blood normally contains 4.5–5.5 million erythrocytes (in men, 4.5–5.5 million; in women, 4–4.5 million). The constancy of the number of erythrocytes in the blood is the result of an equilibrium between their formation in the bone marrow (hematopoiesis) and the destruction of old erythrocytes in the cells of the reticuloendothelial system. The average hemoglobin content in men is 13.3–18 g percent; in women, 11.7–15.8 g percent. The diameter of the human erythrocyte is 7.2 μm; the thickness, 2 μm; and the volume, 88 cu μm. The shape of the biconcave disk ensures passage of the erythrocytes through the narrow lumina of the capillaries. According to A. L. Chizhevskii, the flow of blood is a single, structured, dynamic system comprising a huge number of elements. The movement of the erythrocyte through the vascular channel is not chaotic; this is a consequence both of limited space and of electrostatic, hydro-dynamic, and other forces that inhibit approach and contact between erythrocytes.
The principal function of erythrocytes, the transport of O2 and CO2, can be accomplished thanks to the large content of hemoglobin (about 265 million molecules of hemoglobin in every erythrocyte), the high activity of the enzyme carboanhydrase, the large concentration of 2,3-diphosphoglyceric acid, and the presence of ATP and ADP (adenosine phosphoric acids). These compounds (mainly 2,3-diphosphoglyceric acid) bond with deoxyhemoglobin and decrease its affinity for O2, promoting the liberation of oxygen to the tissues. Erythrocytes have an important role in water-salt metabolism, in the regulation of the body’s acid-base equilibrium, and in the regulation (by absorption) of the body’s amino acid and polypeptide content. Erythrocytes are also the carriers of the properties that define blood groups.
The leukocytes are nucleated cells; they are subdivided into granular leukocytes, or granulocytes (comprising the neutrophils, the eosinophils, and the basophils), and agranular leukocytes, or agranulocytes. Neutrophils are characterized by their ability to move and to penetrate from the loci of hematopoiesis to the peripheral blood and tissues. They are capable of capturing (phagocytizing) microbes and other foreign particles that enter the body. Agranulocytes participate in immunological reactions and in the processes of regeneration and inflammation. There are 6,000–8,000 leukocytes per cu mm in the blood of an adult human.
Thrombocytes, or blood platelets, play an important role in stemming blood flow (clotting). There are 200,000–400,000 thrombocytes per cu mm of human blood. Thrombocytes are nonnucleated. Analogous functions in the blood of all other vertebrates are performed by nucleated spindle cells. The relative constancy of the number of formed elements in the blood is regulated by complex nervous (central and peripheral) and humoral-hormonal mechanisms.
Physicochemical properties. The density and viscosity of blood depend mainly on the number of formed elements. Normally they vary within narrow limits. In man, the density of whole blood is 1.05–1.06 g/cm3; of plasma, 1.02–1.03 g/cm3; and of formed elements, 1.09 g/cm3. The difference in densities makes it possible to separate whole blood into plasma and formed elements by centrifugation. The erythrocytes constitute 44 percent, and the leukocytes and thrombocytes, 1 percent, of the total volume of blood. The osmotic pressure of blood, equal to 740 kilonewtons/m2 (7.63 atmospheres) at 37°C, is determined predominantly by electrolytes—that is, in the plasma, by Na and Cl ions, and in the erythrocytes, by K and Cl ions. The oncotic pressure is determined by the proteins present in the blood. The hydrogen ion concentration is slightly alkaline (pH 7.26–7.36) and is maintained at a constant level by the blood’s buffering systems—bicarbonate, phosphate, and protein—and by the activity of the respiratory and excretory organs.
Chemical composition. There are 18–24 g of dry residue and 77–82 g of water per 100 ml of blood. The water makes up more than half the mass of the erythrocytes and 90–92 percent of the plasma. The blood plasma contains the intermediate and end products of metabolism, as well as salts, hormones, vitamins, and enzymes. A substantial portion of the blood is composed of proteins. These proteins are represented principally by respiratory pigments, the proteins of the erythrocytic stroma, and the proteins of the other formed elements. Proteins dissolved in the plasma (6.5–8.5 percent of the 9–10 percent dry residue of plasma) are formed predominantly in the cells of the liver and reticuloendothelial system. Plasma proteins do not penetrate capillary walls, so that their content in the plasma is significantly higher than in the interstitial fluid. This leads to the retention of water by the plasma proteins. Despite the fact that oncotic pressure accounts for only a small fraction (about 0.5 percent) of the total osmotic pressure, it is the oncotic pressure that causes the preponderance of the osmotic pressure of blood over that of interstitial fluid. The high hydrodynamic pressure in the circulatory system would otherwise cause water to infiltrate the tissues and produce edema of the various organs and subcutaneous tissue.
Proteins also determine the blood’s viscosity, which is five or six times higher than that of water and plays an important role in maintaining the circulatory system’s hemodynamic relationships. Plasma proteins perform a transport function, participate in the regulation of the blood’s acid-base equilibrium, and serve as a nitrogen reserve. A significant portion of the serum calcium, iron, and magnesium are bound to plasma proteins. Fibrinogen, prothrombin, and other proteins participate in blood coagulation. Other plasma proteins play an important role in immune processes.
Plasma proteins are separated by means of electrophoresis into the albumin fraction, the globulin group (α1, α2, β, and γ), and fibrinogen (which participates in blood coagulation). The protein fractions of plasma are not homogeneous; using modern chemical and physicochemical separation methods, it has been possible to discover about 100 protein components of plasma.
Albumins account for 55–60 percent of the proteins of plasma. Because of their relatively small molecules, their high concentration in the plasma, and their hydrophilic properties, the proteins of the albumin group play an important role in maintaining oncotic pressure. Albumins transport organic compounds, such as cholesterol and bile pigments, and serve as a source of nitrogen for the building of proteins. The free sulfhydryl (—SH) group of albumin binds heavy metals, such as mercury compounds, which are deposited in the kidneys until being eliminated from the body. Albumins are capable of combining with certain medicinal substances, such as penicillin and salicylates, and of binding calcium, magnesium, and manganese.
Globulins are an extremely varied group of proteins, differing in physical and chemical properties and in functional activity. With paper electrophoresis they can be separated into α1, α2, β, and γ-globulins. Most of the proteins of the α- and α-globulin fractions are bound to carbohydrates (glycoproteins) or lipids (lipoproteins). Sugar or amino sugars are usually among the components of the glycoproteins. Blood lipoproteins, which are synthesized in the liver, are separated by their electrophoretic mobility into three principal fractions, differing in lipid composition. The physiological role of lipoproteins consists in delivering water-insoluble lipids, steroid hormones, and fat-soluble vitamins to the tissues.
The α2-globulin fraction comprises several proteins that participate in blood coagulation, including prothrombin, an inactive precursor of the enzyme thrombin that produces the conversion of fibrinogen to fibrin. The fraction also includes haptoglobin, whose content in the blood increases with age. Haptoglobin forms a complex with hemoglobin that is absorbed by the reticuloendothelial system. This prevents the body’s loss of iron, a component of hemoglobin. In addition, the α2-globulins include the glycoprotein ceruloplasmin, which contains 0.34 percent copper (that is, almost all plasma copper). Ceruloplasmin catalyzes the oxidation by oxygen of ascorbic acid and aromatic diamines.
The α2-globulin fraction of the plasma contains the polypep-tides bradykininogen and kallidinogen, which are activated by proteolytic enzymes of the plasma and tissues. Their active forms, bradykinin and kallidin, form the kinin system, which regulates the permeability of the capillary walls and activates the coagulation system of the blood.
The glycoproteins of the β-globulin fraction include transferrin, the carrier of iron in the body. The β1- and β2-globulin fractions contain several of the coagulation factors of the plasma, including antihemophilic globulin.
Fibrinogen migrates between β- and γ-globulins. The plasma proteins that migrate with the γ-globulins include the various antibodies, such as the antibodies to diphtheria, whooping cough, measles, scarlet fever, and poliomyelitis.
The nonprotein nitrogen of the blood is contained mainly in the end or intermediate products of nitrogenous metabolism: urea, ammonia, polypeptides, amino acids, creatine, creatinine, uric acid, and purine bases. The blood that flows away from the intestinal tract carries amino acids through the portal vein to the liver, where the amino acids undergo deamination, reamination, and other transformations (to the formation of urea) and where they are used for the biosynthesis of protein.
Blood carbohydrates are represented mainly by glucose and the intermediate products of its conversions. The glucose content of the blood varies in man from 80 to 100 mg percent. The blood also contains small amounts of glycogen and fructose and a significant amount of glucosamine. The products of the digestion of carbohydrates and proteins—glucose, fructose, other monosaccharides, amino acids, and low-molecular-weight peptides, as well as salts and water—are absorbed directly into the blood flowing through the capillaries of the intestine and delivered to the liver. Some of the glucose is transported to the organs and tissues, where it breaks down, releasing energy. The rest is converted to glycogen in the liver. When the intake of carbohydrates with the food is insufficient, this glycogen breaks down to form glucose. These processes are regulated by the enzymes of carbohydrate metabolism, by the central nervous system, and by the endocrine glands.
The blood contains a complex mixture of lipids that consist of neutral fats and free fatty acids and the products of their decomposition, free and bound cholesterol, steroid hormones, and other substances. Neutral fats, glycerin, and fatty acids are absorbed from the mucosa of the intestine partially into the blood but mainly into the lymph. The amount of lipids in the blood is not constant and depends on the composition of the diet and the stage of digestion. The blood transports lipids in the form of various complexes; a large proportion of both the plasma lipids and the cholesterol in the blood is found in the form of lipo-proteins, bound with α- and β-globulins. Free fatty acids are transported in the form of complexes with albumins, which are soluble in water. Triglycerides form compounds with phosphatides and proteins. The blood transports a fatty emulsion to the depots of adipose tissue, where it is deposited in the form of reserve fat and can, when needed, again be transferred to the blood plasma (fats and the products of their decomposition are used for the energy requirements of the body). The principal organic components of the blood are shown in Table 1.
Mineral substances maintain the blood’s active reaction (pH) and the constancy of the blood’s osmotic pressure and influence the state of blood colloids and intracellular metabolism. Sodium (Na) and chlorine (Cl) are the principal plasma minerals, and potassium (K) is found predominantly in the erythrocytes. Sodium participates in water metabolism, holding water in the tissues by swelling colloidal matter. Chlorine, which penetrates readily from the plasma into the erythrocytes, participates in the maintenance of the blood’s acid-base equilibrium. Calcium (Ca), which is necessary for clotting, is found in the plasma, mostly as ions or bound to proteins. HCO3- ions and dissolved carbonic acid form the bicarbonate buffer system. HPO4- and H2PO4- ions form the phosphate buffer system. A number of other anions and cations, including those of microelements, are found in the blood.
In addition to the compounds that are transported by the blood to the various organs and tissues to be used for biosynthesis, energy, and other body needs, metabolic products are continuously entering the blood and being excreted by the kidneys with the urine (mainly urea and uric acid). The products of hemoglobin decomposition (mainly bilirubin) are excreted with the bile.
REFERENCESChizhevskii, A. L. Strukturnyi analiz dvizhushcheisia krovi Moscow, 1959.
Korzhuev, P. A. Gemoglobin. Moscow, 1964.
Haurowitz, F. Khimiia i funktsiia belkov. Moscow, 1965. (Translated from English.)
|Table 1. Most important organic components of human whole blood, plasma, and erythrocytes|
|Water (%). . . . . . . . . .||75-85||90-91||57-68|
|Dry residue (%). . . . . . . . . .||15-25||9-10||32-43|
|Hemoglobin (%). . . . . . . . . .||13-16||—||30-41|
|Total protein (%). . . . . . . . . .||—||6.5-8.5||—|
|Fibrinogen (%). . . . . . . . . .||—||0.2-0.4||—|
|Globulins (%). . . . . . . . . .||—||2.0-3.0||—|
|Albumins (%). . . . . . . . . .||—||4.0-5.0||—|
|Residual nitrogen (nitrogen of nonprotein compounds; mg % ). . . . . . . . . .||25-35||20-30||30-40|
|Glutathione (mg %). . . . . . . . . .||35-45||traces||75-120|
|Urea (mg %). . . . . . . . . .||20-30||20-30||20-30|
|Uric acid (mg %). . . . . . . . . .||3-4||4-5||2-3|
|Creatinine (mg %). . . . . . . . . .||1-2||1-2||1-2|
|Creatine (mg %). . . . . . . . . .||3-5||1-1.5||6-10|
|Amino-acid nitrogen (mg %). . . . . . . . . .||6-8||4-6||8|
|Glucose (mg %). . . . . . . . . .||80-100||80-120||—|
|Glucosamine (mg %). . . . . . . . . .||—||70-90||—|
|Total lipids (mg %). . . . . . . . . .||400-720||385-675||410-780|
|Neutral fats (mg %). . . . . . . . . .||85-235||100-250||11-150|
|Total cholesterol (mg %). . . . . . . . . .||150-200||150-250||175|
|Indican (mg %). . . . . . . . . .||—||0.03-0.1||—|
|Kinins (mg %). . . . . . . . . .||—||1-20||—|
|Guanidine (mg %). . . . . . . . . .||—||0.3-0.5||—|
|Phospholipids (mg %). . . . . . . . . .||—||220-400||—|
|Lecithin (mg %). . . . . . . . . .||about 200||100-200||350|
|Ketone bodies (mg %). . . . . . . . . .||—||0.8-3.0||—|
|Acetoacetic acid (mg %). . . . . . . . . .||—||0.5-2.0||—|
|Acetone (mg %). . . . . . . . . .||—||0.2-0.3||—|
|Lactic acid (mg %). . . . . . . . . .||—||10-20||—|
|Pyruvic acid (mg %). . . . . . . . . .||—||0.8-1.2||—|
|Citric acid (mg %). . . . . . . . . .||—||2.0-3.0||—|
|Ketoglutaric acid (mg %). . . . . . . . . .||—||0.8||—|
|Succinic acid (mg %). . . . . . . . . .||—||0.5||—|
|Bilirubin (mg %). . . . . . . . . .||—||0.25-1.5||—|
|Choline (mg %). . . . . . . . . .||—||18-30||—|
Prosser, L., and F. Brown. Sravnitel’naia fiziologiia zhivotnykh. Moscow, 1967. (Translated from English.)
Vvedenie v klinicheskuiu biokhimiiu. Edited by I. I. Ivanov. Leningrad, 1969.
Kassirskii, I. A., and G. A. Alekseev. Klinicheskaia gematologiia, 4th ed. Moscow, 1970.
Semenov, N. V. Biokhimicheskie komponenty i konstanty zhidkikh sred i tkanei cheloveka. Moscow, 1971.
Biochimie médicale, 6th ed., fasc. 3. Paris, 1961.
The Encyclopedia of Biochemistry. Edited by R. J. Williams and E. M. Lansford. New York, 1967.
Brewer, G. J., and J. W. Eaton. “Erythrocyte Metabolism.” Science, 1971, vol. 171, p. 1205.
The Red Cell: Metabolism and Function. Edited by G. J. Brewer. New York-London, 1970.
When erythrocytes regenerate after blood loss or in the presence of intensive erythrocytic decomposition (hemolysis), altered erythrocytes and reticulocytes (erythrocytes with a granuloreticulate substance) appear in the peripheral blood. A sharp intensification of new growth of erythrocytes leads to the appearance of young forms: normoblasts, erythroblasts, and, in severe cases, megaloblasts.
The number of white cells in the blood (leukocytes) may also change. Cases of increased leukocytes, called leukocytoses, appear with certain physiological conditions and in various pathological states. Decreased leukocyte content is called leukopenia. It is seen mainly with a suppression of hematopoiesis in the bone marrow. Change in the amount of various types of leukocytes in the blood plays an important role in the diagnosis and prognosis of disease.
The thrombocyte content of the blood increases (thrombocytosis) after bleeding, in certain diseases of the blood system, such as myeloleukosis, polycythemia, and hemorrhagic thrombocythemia, and with certain tumor diseases. A decrease in the number of thrombocytes (thrombocytopenia) occurs under the influence of radiation and chemical factors, with immunoaggressive diseases, and in certain diseases of the blood system. A low thrombocyte count is manifested in the form of thrombocytopenic purpura, or Werlhof’s disease. The normal course of blood coagulation, in which the thrombocytes participate (along with other factors), depends on the balance between the clotting and anticlotting systems of the blood. Disruption of this balance may produce increased susceptibility to bleeding, which is observed in hemophilia, hemorrhagic diatheses, disturbances of vitaminK absorption (obstructive jaundices), and thromboembolic disease (increased thrombogenesis).
In a number of pathological states there is a change in blood volume. An increase in blood volume (hypervolemia) may occur without change in the proportion between the volumes of plasma and erythrocytes, or it may occur chiefly through an increase in the cell mass (true plethora, or polycythemic hypervolemia). A decrease in blood volume (hypovolemia) occurs as a result of loss of plasma (with intractable vomiting, diarrhea, or overheating) or loss of erythrocytic mass (as a result of hemorrhage).
Blood changes may be reactive—that is, they may arise as a responsive physiological reaction to stresses: blood loss, infection (bacterial, viral, or parasitic), or the entry into the body of toxic substances or allergens of external or internal origin. Pathological (nonreactive) changes in the blood arise in connection with diseases of the blood system or of the hematopoietic system. The etiologies of a number of these diseases (in particular, of leukemias) remain unelucidated.
Complex analysis of these blood factors makes it possible to distinguish several large population groups that do not coincide entirely with the large races but are found to be in definite correlation with them. Serological differences are being traced between the Caucasoid, Negroid, Australoid, and Mongoloid (including American Indian) populations.
Various serological complexes that are characteristic of certain populations arise and change in the course of time as a result of mutations, prolonged isolation, and racial mixing. However, the blood is qualitatively equivalent in all peoples and races, and no blood group has advantages over any other.
Many serological features are also being studied from the point of view of physiological anthropology, including such widely varying indexes as the levels in the blood of proteins, lipids (particularly cholesterol), carbohydrates, and enzymes. The quantitative content of these components, unlike blood groups, is closely associated with living conditions.
Fossil bone material is also being investigated in order to elucidate group serological characteristics and the connections between different groups of prehistoric and modern man and animals. The blood groups of monkeys are being studied for this purpose. In addition, the genetically determined blood factors in primates are being compared in terms of evolution. These investigations have made substantial contributions to primate taxonomy.
REFERENCESCheboksarov, N. N., and I. A. Cheboksarova. Narody, rosy, kul’tury. Moscow, 1971.
Biologiia cheloveka. Moscow, 1968. (Translated from English.)
V. A. SPITSYN
What does it mean when you dream about blood?
Blood has a rich and complex symbology and can represent any number of different kinds of human experiences. Because of certain familiar experiences and metaphors, many of these do not require explanation (e.g., menstrual blood may symbolize fertility; one can be “bled dry”; one may have “blood on one’s hands”). Blood often represents vitality and the life force. Images of confused, bloody violence often occur in the dreams of people undergoing some sort of emotional upheaval.