PER, perineurium; ma, myelinated nerve fibres; s, Schwann cells, o, oedema; u, unmyelinated
The electrical field produced by PRF can change pain signals and has selective effect on small unmyelinated
fibres (C fibres) [37, 38].
The mossy fibers are the only axonal tracts exclusively containing unmyelinated
Whereas the morphological characteristics of axons that were myelinated and unmyelinated
were maintained in the C (Figure 2a), S (Figure 2c) and SI (Figure 2d) groups, deterioration of axonal morphology and reduction of myelin thickness and the number of myelinated/unmyelinated axons were observed only in the I (Figure 2b) group.
Odiete (1978) illustrated in this species a sort of concentrically lamellar figures that were deemed as myelinated axons (but this was only in small-sized ones), stating, however, that most axons entering the medulla were typical unmyelinated
. The electron microscopy approach was not an extensive study herein, and, eventually, it may have missed such kind of structures.
In patients with neuropathic pain (NP), TRPV1 is expressed through the nociceptive pathway, from unmyelinated
axons in the skin to the back of the spinal cord .
Eye and brain come from the same embryological origin and the eye's retina has unmyelinated
axons and a relatively lower concentration of glial cells [17, 26].
In these small lightly myelinated and unmyelinated
nerve fibers, [alpha]-synuclein deposits are present even in the early stages of PD as demonstrated by an analysis of skin biopsies immunohistochemically costained for [alpha]-synuclein and nerve fibers .
The axons consisted of both myelinated and unmyelinated
However, the foot withdrawal reflex in response to heat stimuli, which involves unmyelinated
fibers, failed to show full recovery at the end of the study.
(18) Quantitative sensory testing enables thermal testing of unmyelinated
C fibres and myelinated AS fibres mediating cold sensation.