up-and-down method

up-and-down method

[¦əp ən ′dau̇n ‚meth·əd]
(statistics)
A technique which uses a unit sequential method of testing; the level of variable at each experiment is raised or lowered depending on the outcome of the previous test.
References in periodicals archive ?
It was clearly mentioned in the initial study that the sample size was based on the up-and-down method of Dixon, according to which at least six independent pairs of patients with no hypotension/hypotension (response/no response pairs) should provide reliable estimates of the minimum effective dose of vasopressor [([ED.sub.50]).sup.3].