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Related to uraemia: azotemia


(yo͝orē`mēə), condition resulting from advanced stages of kidney failure in which urea and other nitrogen-containing wastes are found in the blood. Uremia can be caused by NSAIDs (nonsteroid anti-inflammatory drugs), especially in older patients treated primarily with ibuprofenibuprofen
, nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxen and ketoprofen, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967.
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 for arthritis. Some of the early signs of uremia are lethargy, mental depression, loss of appetite, and edema; later symptoms include diarrhea, anemia, convulsions, coma, and a gray-brown coloration. Treatment of uremia, which is directed at the underlying kidney disease, is usually with dialysis and renal transplantation. Treatments with genetically engineered erythropoietin decrease the complication of anemia. See nephritisnephritis
, inflammation of the kidney. The earliest finding is within the renal capillaries (glomeruli); interstitial edema is typically followed by interstitial infiltration of lymphocytes, plasma cells, eosinophils, and a small number of polymorphonuclear leukocytes.
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; nephrosisnephrosis
, kidney disease characterized by lesions of the epithelial lining of the renal tubules, resulting in marked disturbance in the filtration function and the consequent appearance of large amounts of protein (albumin) in the urine (see urinary system).
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The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a toxic condition caused by severe impairment of renal function. It may be acute or chronic.

Acute uremia occurs in acute renal insufficiency during oliguria and is marked by severe impairment as well as by systemic disorders. The concentration of creatinine, urea, indican, ammonia, and other nitrogenous compounds increases markedly in the blood, resulting in azotemia. The content of such electrolytes as potassium, magnesium, calcium, and chlorine becomes altered, the acid-base balance is disturbed, resulting in acidosis, and water is retained in the body. Cardiovascular changes are manifested by tachycardia, arrhythmia, and hypertension. Other symtoms include anemia, digestive disorders, neurological disturbances, and often pulmonary edema. Acute uremia persists for five to ten days and sometimes up to 30 days or longer. The majority of persons affected with the disease return to work in three to 12 months.

Chronic uremia (terminal uremia, or terminal chronic renal insufficiency) is caused by many chronic kidney diseases. Affected persons experience lassitude, become emotionally unstable, and exhibit various types of neuromuscular phenomena. Hearing is impaired and the skin becomes pale yellow in color and is dry, flaccid, and painfully itchy. Other common symptoms are loss of appetite, nausea, vomiting, thirst, convulsions, polyneuritis, and nasal, cutaneous, or intestinal hemorrhages. The process of change in the electrolytes intensifies, and azotemia and acidosis become more marked. The bones decalcify and the joints are affected. Blood pressure rises sharply and pericarditis develops. The specific gravity of the urine remains low.

The treatment of uremia is conservative; methods used include cleansing of the blood by means of an artifical kidney or by peritoneal dialysis. A kidney transplant may be indicated.


Osnovy nefrologii, vol. 1. Edited by E. M. Tareev. Moscow, 1972. Pages 164–234.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


A condition resulting from kidney failure and characterized by azotemia, chronic acidosis, anemia, and a variety of systemic signs and symptoms.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Other effects of uraemia include pruritis, peripheral neuropathy, mouth ulcers, pancreatitis, sexual dysfunction and infertility.
Restricting protein intake in CKD can delay progression of the disease and reduce adverse cardiovascular effects and uraemia (12).
Confusion, Uraemia, Respiratory rate, Blood pressure, age > 65 years recommendation for each patient was determined at the time of analysis.
Anaemia was a frequent clinical comorbidity associated with abdominal wound dehiscence in 37 cases (66.07%), intra-abdominal infection/sepsis was present in 43 cases (76.78%), uraemia was seen in 11 cases (19.64%), diabetes mellitus in 10 cases (17.86%), hypertension in 14 cases (25%), obesity in 20 cases (35.71%), jaundice in 5 cases (8.93%), and malignancy in 3 cases (5.36%).
Patient was discharged home after one week when her urine infection was controlled and uraemia improved.
Clinicians who had insight into the physiology of uraemia worried, nevertheless, that if patients receiving haemodialysis were to achieve optimum results they needed to have more frequent and longer treatments.
Influence of uraemia on the determination of blood glycohaemoglobin by HPLC, electrophoresis and affnity chromatography in diabetic and non-diabetic patients.
The normal physiological process of coagulation and the effects of uraemia on this need to be clearly understood.
Uraemia per se has been shown to cause a pleuritis by an unknown mechanism.
Patients with ESRF commonly experience sleep disturbances that can be due to uraemia, duration of dialysis therapy and chronic pain (Wallace-Williams et al.
They are considered to be characteristic of uraemia. It can involve all finger- and toenails.