Uricase

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Related to urate oxidase: uricase, allopurinol

uricase

[′yu̇r·ə‚kās]
(biochemistry)
An enzyme present in the liver, spleen, and kidney of most mammals except humans; converts uric acid to allantoin in the presence of gaseous oxygen.

Uricase

 

an oxidoreductase enzyme that catalyzes the oxidation of uric acid to allantoin during the decomposition of purine bases in animals other than primates. Uricase is also found in plants.

References in periodicals archive ?
A recombinant urate oxidase enzyme, rasburicase converts existing uric acid to allantoin, which is 5 to 10 times more soluble in urine than uric acid.
Pegloticase is a pegylated recombinant mammalian urate oxidase in development to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been ineffective.
Discovered by Sanofi-Synthelabo, rasburicase is a genetically derived urate oxidase.
Sanofi-Synthelabo has several oncology products in late stages of development including oxaliplatin, urate oxidase and tirapazamine.
Puricase is a pegylated recombinant mammalian urate oxidase being developed to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been ineffective.
Puricase is a pegylated recombinant mammalian urate oxidase that is being developed to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been ineffective.