Uricase

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Related to urate oxidase: uricase, allopurinol

uricase

[′yu̇r·ə‚kās]
(biochemistry)
An enzyme present in the liver, spleen, and kidney of most mammals except humans; converts uric acid to allantoin in the presence of gaseous oxygen.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Uricase

 

an oxidoreductase enzyme that catalyzes the oxidation of uric acid to allantoin during the decomposition of purine bases in animals other than primates. Uricase is also found in plants.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/ leukemia before and after introduction of prophylactic use of urate oxidase. Ann Hematol.
Pan-European multicentre economic evaluation of recombinant urate oxidase (rasburicase) in prevention and treatment of hyperuricaemia and tumor lysis syndrome in haematological cancer patients.
Additionally, none of the patients received urate oxidase and 7% required hemodialysis.
Pinkerton et al., "Rasburicase (recombinant urate oxidase) for the management of hyperuricemia in patients with cancer: Report of an international compassionate use study," Cancer, vol.
Exploring new resources for urate oxidase is steel required due to its rising significance in therapy and in diagnostic tests and for finding more economic sources.
Allopurinol and Febuxostat and recombinant urate oxidase. Other options include weight loss, regular exercise; avoid risk factors including dietary and medications.
* Pegloticase, a pegylated recombinant form of urate oxidase enzyme that converts uric acid to allantoin (31) (a water-soluble metabolite of uric acid), is a possible therapeutic option for patients who do not achieve adequate serum urate levels and continue to have symptoms of gout.