uremia


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uremia

(yo͝orē`mēə), condition resulting from advanced stages of kidney failure in which urea and other nitrogen-containing wastes are found in the blood. Uremia can be caused by NSAIDs (nonsteroid anti-inflammatory drugs), especially in older patients treated primarily with ibuprofenibuprofen
, nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxen and ketoprofen, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967.
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 for arthritis. Some of the early signs of uremia are lethargy, mental depression, loss of appetite, and edema; later symptoms include diarrhea, anemia, convulsions, coma, and a gray-brown coloration. Treatment of uremia, which is directed at the underlying kidney disease, is usually with dialysis and renal transplantation. Treatments with genetically engineered erythropoietin decrease the complication of anemia. See nephritisnephritis
, inflammation of the kidney. The earliest finding is within the renal capillaries (glomeruli); interstitial edema is typically followed by interstitial infiltration of lymphocytes, plasma cells, eosinophils, and a small number of polymorphonuclear leukocytes.
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; nephrosisnephrosis
, kidney disease characterized by lesions of the epithelial lining of the renal tubules, resulting in marked disturbance in the filtration function and the consequent appearance of large amounts of protein (albumin) in the urine (see urinary system).
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.

Uremia

 

a toxic condition caused by severe impairment of renal function. It may be acute or chronic.

Acute uremia occurs in acute renal insufficiency during oliguria and is marked by severe impairment as well as by systemic disorders. The concentration of creatinine, urea, indican, ammonia, and other nitrogenous compounds increases markedly in the blood, resulting in azotemia. The content of such electrolytes as potassium, magnesium, calcium, and chlorine becomes altered, the acid-base balance is disturbed, resulting in acidosis, and water is retained in the body. Cardiovascular changes are manifested by tachycardia, arrhythmia, and hypertension. Other symtoms include anemia, digestive disorders, neurological disturbances, and often pulmonary edema. Acute uremia persists for five to ten days and sometimes up to 30 days or longer. The majority of persons affected with the disease return to work in three to 12 months.

Chronic uremia (terminal uremia, or terminal chronic renal insufficiency) is caused by many chronic kidney diseases. Affected persons experience lassitude, become emotionally unstable, and exhibit various types of neuromuscular phenomena. Hearing is impaired and the skin becomes pale yellow in color and is dry, flaccid, and painfully itchy. Other common symptoms are loss of appetite, nausea, vomiting, thirst, convulsions, polyneuritis, and nasal, cutaneous, or intestinal hemorrhages. The process of change in the electrolytes intensifies, and azotemia and acidosis become more marked. The bones decalcify and the joints are affected. Blood pressure rises sharply and pericarditis develops. The specific gravity of the urine remains low.

The treatment of uremia is conservative; methods used include cleansing of the blood by means of an artifical kidney or by peritoneal dialysis. A kidney transplant may be indicated.

REFERENCE

Osnovy nefrologii, vol. 1. Edited by E. M. Tareev. Moscow, 1972. Pages 164–234.

N. R. PALEEV

uremia

[yə′rē·mē·ə]
(medicine)
A condition resulting from kidney failure and characterized by azotemia, chronic acidosis, anemia, and a variety of systemic signs and symptoms.
References in periodicals archive ?
Actual uremia was seen less frequently in patients with acute glomerulonephritis and was more commonly associated with chronic disease.
Engaging preventive uremia thinking, one observes impaired defensive ability and superimposed deficiency states of CKD.
Mall, "A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia," Journal of the American Society of Nephrology, vol.
Uremia and compromised renal function are associated with a greater reduction in EPCs availability and function (26), which can contribute to the increased morbidity and mortality of these patients.
The resulting impairment of the excretory, metabolic and endocrine functions of the kidney leads to the development of the clinical syndrome of uremia.
The patient in this case report had a course of severe uremia (UREA: 149, CR: 5.2) over several days.
Complete urethral obstruction from urolithiasis resulting in uremia, leading to death has also been reported by Loreeti et al.
The present study included 19 patients (16 males and 3 females) with simultaneous pancreas-kidney transplantation (SPK) with enteric drainage, involving 11 patients with type 1 diabetes mellitus (T1DM) and 8 patients with type 2 diabetes mellitus (T2DM) both with uremia; 31 diabetic patients (21 males and 10 females) with uremia (chronic renal failure (CRF)), involving 7 patients with T1DM and 24 patients with T2DM; 22 diabetic patients with uremia (13 males and 9 females) who underwent renal transplantation (RT), involving 3 patients with T1DM and 19 patients with T2DM; and 20 (13 males and 7 females) normal individuals (control (CON)) (Table 1).
Our patient had severe renal insufficiency and uremia. The uremic symptoms included confusion, which responded to dialysis.
However, the expression of AQP5 in the sweat glands of the uremia is unclear, although the skin of the CKD patients was much drier than that of normal people.
Such phenotypic changes are consistent with previous studies characterizing neutrophil dysfunction in cerebrovascular inflammation [36] and uremia [37].
Una paciente comenzo con 2 recambios/dia de 1 litro de 1,36% por tener cirrosis y ascitis y otro comenzo con 4 recambios de 0,5 litros por uremia y comenzar justo despues de colocar el cateter de DP.