In addition, four dihydroorotase genes, two dihydroorotate dehydrogenase genes, three uridine monophosphate
synthetase genes, two 5'-nucleotidase genes, one uridine nucleosidase gene, one udk gene, two UMP-CMP kinase genes, one ndk gene, one apyrase gene, one ITPA gene, one CTP synthase gene, and one cdd gene were successfully cloned (Figure S4, Supporting Information).
Souvenaid, a product not yet available, contains EPA, DHA, choline, uridine monophosphate
, B vitamins, and a mixture of antioxidants.
Three active principles are interlocked: ethyl ferulate, a natural antioxidant with UV absorbing properties, neutralizes dangerous oxygen radicals and reduces the dose of UV radiation which penetrates the skin; camosolic acid, which combats free radicals--one of the main causes of DNA and cell damage; and uridine monophosphate
(UMP), a biochemical precursor to the synthesis of nucleotides, supports the repair of DNA in the cell.
Resistance to 5-FOA can be achieved by blocking the pyrimidine pathway through mutational inactivation of orotidine-5'-monophosphate (OMP) decarboxylase which catalyzes the decarboxylation of orotidine monophosphate (OMP) to form uridine monophosphate
* Uridine monophosphate
, 625 mg: Required for the formation of RNA and DNA, which are essential for proper brain function, and for signaling molecules involved in memory and other brain functions.
Principally, the intermediate metabolite fluorodeoxj uridine monophosphate
inhibits a key enzyme in pyrimidine biosynthesis, namely thymidylate synthase (TS).