urocanic acid


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urocanic acid

[¦yu̇r·ə¦kan·ik ′as·əd]
(biochemistry)
C6H6N2O2 A crystalline compound formed as an intermediate in the degradative pathway of histidine.
References in periodicals archive ?
The FLG-derived histidine-rich proteins are converted into urocanic acid (UCA) and pyrrolidine carboxylic acid (PCA) by proteases.
He described how a nature-inspired urocanic acid product, called cis-methylthiopropenoic acid conjugate (MTPC), prevents DNA damage and immunosuppressive signaling induced by UVB radiation.
Based on laboratory investigations, the authors first assumed that the megaloblastic hematopoiesis accompanied by urinary excretion of large amounts of urocanic acid following oral dose of histidine hydrochloride was responsible for aplastic crisis in these patients with HS.
He recently has focused on a specific skin-barrier protein called filaggrin, which is broken down into a molecule called urocanic acid the most potent absorber of UVB light in the skin, according to Elias.
Great differences were observed in the utilization of L-arabinose, urocanic acid, [alpha]-glycerol-phosphate, glucose-1-phosphate, and glucose-6-phosphate which were positive for 14%, 18%, 50%, 47%, and 33% of the strains, respectively, instead of not being preferred as a sole carbon source.
When filaggrin deficiency is present, trans urocanic acid (UCA) does not form.
The urocanic acid acts as a natural sunscreen of skin of animals and humans.
One such compound is urocanic acid found on the epidermis layer of human skin and more prevalent when sweating.
Skin: The skin is naturally protected from the sun's radiation by the thickness of the epidermis, melanin, natural antioxidants, DNA repair mechanism, Urocanic acid and Fas ligand signaling.
A further 8 treatments (humic acid, mannitol, sucrose, root exudates, thiamin, urocanic acid, cellulose, fulvic acid) showed an increase in the amount of cumulative C[O.sub.2]-C respired compared with the control solution, but this was less than or equivalent to the total amount of substrate applied (30 [micro]g C/g soil; Fig.
The physical properties of the substances, melanin and urocanic acid, change with exposure to ultraviolet (UV) light.