The significantly reduced parasitism observed with oral administration of compound 1 may be due to its low absorption in the bowels, as verified in a recent study evaluating ursolic acid
pharmacokinetics after oral administration (Jeong et al.
The findings suggested that the substance known as ursolic acid
reduces obesity and its associated health problems by increasing the amount of muscle and brown fat, two tissues recognized for their calorie-burning properties.
Researcher Dr Chris Adams of the University of Iowa and his colleagues added the chemical, called ursolic acid
, to food given to laboratory mice.
Comparison of those gene expression signatures to the signatures of cells treated with more than 1300 bioactive small molecules led them to ursolic acid
as a compound with effects that might counteract those of atrophy.
A natural compound found in the apple's skin, called ursolic acid
, may help prevent muscle wasting that can result from again and illness.
Park, In Vivo Anti-Nociceptive and Anti-Inflammatory Effect of the Two Triterpenes, Ursolic Acid
and 23 Hydroxyursolic Acid, from Cussonia bancoensis, Arch.
Among the various bio-active constituents reported from Bignoniaceae family plantsand reviewed in the present study, some of the more common but pharmacologically important compounds are ursolic acid
, oleanolic acid, a- and b-lapachone, lapachol, verbascoside, corymboside, lupeol, quercitrin, apigenin, pomolic acid, and isoacteoside.
Ltd, Bangalore), a polyherbal formulation, was as follows: Withania somnifera 17 per cent (aqueous extract of root: withanolides 2% w/w), Ocimum sanctum 17 per cent (70% alcohol extract of leaves: ursolic acid
3% w/w), Camellia sinensis 33 per cent (70% alcohol extract of leaves: total polyphenols 60% w/w), triphala 25 per cent (aqueous extract: total tannin 34% w/w) and shilajit 8 per cent (aqueous extract: fulvic acid 53% w/w; humic acid 17% w/w).
Compounds such as curcumin (found in turmeric), resveratrol (grapes), lycopene (tomato), ursolic acid
(basil, prunes and plums), gingerol (ginger), ellagic acid (pomegranate, berries, walnuts), emodin (aloe vera), sulforaphane (cruciferous vegetables), linalool (coriander), genistein (soybeans) and anethole (fennel), just to name a few, may interfere with the many cell signals needed to turn on one of the event cascades that can trigger cancer growth and development.
These compounds include eugenol, camphor, caryophyllene, ursolic acid
, rosmarinic acid, luteolin, and apigenin.
* Anti-aging products: Some of these ingredients, like chaparral and white tea, address wrinkles while others, such as ursolic acid
from the botanical uva ursi, deal with lightening skin tone.
umbrosa tested against degeneration of retinal ganglion cells was found to be associated with a wide variety of compounds including ursolic acid
, oleanolic acid-3-O-[alpha]-L-rhamnopyranoside, daucosterol, hederagenin-3-O-[alpha]-L-arabinopyranoside, sweroside, caffeic acid, esculetine, 3,4-dihydroxy benzaldehyde, loganin, and vanilic acid.