As the most potential live biotherapeutic agent, vaccinia
virus (VACV) have been used for in vitro and in vivo studies, and clinical trials.
Reemergence of vaccinia
virus during zoonotic outbreak, Para State, Brazil.
virus and Pseudocowpox virus co-infection: Clinical description and phylogenetic characterization.
Although the vaccinia
virus has been shown to preferably trigger programmed necrosis we reported in our previous investigation that the double recombinant vaccinia
virus VV-GMCSF-Lact, coding proapoptotic protein lactaptin and human GM-CSF, induced cancer cell death with caspase-3 and caspase-7 activation [6, 24].
Although inadvertent inoculation is a recognized adverse event following vaccination with vaccinia
virus, neither NMDOH nor four of five other public health departments were aware that this study was being conducted, demonstrating the need for communication among commercial sites and state and local health departments to ensure establishment of mutually acceptable patient care protocols.
However, large-scale use of the vaccinia
virus as an expression system has raised various safety issues over its broad host range, ability to infect and cause disease among laboratory personals handling it.
Gholami and her colleagues at MSKCC wanted to determine whether a new vaccinia
virus, called GLV-1h164, carrying a protein that targets vascular endothelial growth factor (VEGF), could destroy TNBC tumors in a mouse animal model.
virus is best known as the basis of the vaccine that eradicated smallpox.
Scientists have known for many years that the well-studied vaccinia
poxvirus uses two proteins to inhibit the protein kinase R response.
" While these results are very interesting and hopefully may lead to a new weapon against the HIV pandemic, they are preliminary and it is far too soon to recommend the general use of vaccinia
immunisation for fighting HIV," the team said.
Smallpox was eradicated worldwide in 1980, after a large vaccination campaign, in which Vaccinia
virus was used as a vaccinal vector, due to its high genetic similarity with the smallpox virus.
He eventually recovered, but subsequent test results showed he had suffered from vaccinia
virus infection that did not match the type of virus strain used in experiments in the laboratory where he worked.