globulin

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globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
([section]) Vaccinia Immune Globulin Intravenous (Human).
The introduction of intramuscularly administered vaccinia immune globulin treatment was estimated to have reduced EV-associated mortality from 30%--40% to 7% (9).
Vaccinia immune globulin release and vaccinia transmission to contacts--United States, January 24-December 31, 2003 No.
During May 10-June 20, no vaccinia immune globulin was released for civilian vaccinees in the pre-event vaccination program, excluding persons involved in investigational new drug studies.
TABLE 3 Vaccinia immune globulin release and vaccinia transmission to contacts -- United States, January 24-May 9, 2003 No.
TABLE 3 Vaccinia immune globulin release vaccinia transmission to contacts -- United States, January 24-May 2, 2003 No.new Total cases (January 24- Events (April 26-May 2) May 2) Vaccinia immune globulin release 0 1 Vaccinia transmission to contacts * health-care settings 0 0 Other settings 0 0 * No cases of transmission from civilian vaccinees have been reported.
TABLE 3 Vaccinia immune globulin release and vaccina transmission to contacts - United States, January 24-April 25, 2003 No.
TABLE 4 Number of vaccinia immune globulin releases and vaccinia transmissions to contacts--United States, January 24-March 30, 2003 Total no.
new cases Other serious adverse events n 4 Other nonserious adverse events ** 30 Vaccinia immune globulin release 0 Vaccinia transmission to contacts 0 ++ Adverse events Suspected Probable Total no.
The patient improved within 24 hours after treatment with trifluridine eyedrops and a single dose of intravenous vaccinia immune globulin. She was discharged on February 28.
cases Other events of concern Other serious adverse events (ss) -- Other nonserious adverse events (n) 7 Vaccinia immune globulin release -- Vaccinia transmission to contacts -- * Under investigation or completed as of February 18, 2002; numbers and classifications of adverse events will be updated regularly in MMWR as more information becomes available.