vancomycin


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vancomycin

(văn'kōmī`sĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 resembling penicillinpenicillin,
any of a group of chemically similar substances obtained from molds of the genus Penicillium that were the first antibiotic agents to be used successfully in the treatment of bacterial infections in humans.
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 in the way it acts. It is derived from the bacterium Streptomyces orientalis, which was isolated from soil of India and Indonesia. Vancomycin destroys Gram-positive bacteria, especially staphylococci and enterococci (see Gram's stainGram's stain,
laboratory staining technique that distinguishes between two groups of bacteria by the identification of differences in the structure of their cell walls. The Gram stain, named after its developer, Danish bacteriologist Christian Gram, has become an important tool
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). It seems to function by inhibiting the formation of the bacterial cell wall, as does penicillin; it may also cause damage to the cell membrane. The drug is intensely irritating to tissues and is usually used only for infections where microorganisms are resistant to penicillin (see drug resistancedrug resistance,
condition in which infecting bacteria can resist the destructive effects of drugs such as antibiotics and sulfa drugs. Drug resistance has become a serious public health problem, since many disease-causing bacteria are no longer susceptible to previously
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). Vancomycin must be administered intravenously because it is not absorbed through the gastrointestinal tract. Mutant microorganisms resistant to vancomycin are rare.

vancomycin

[‚vaŋ·kə′mīs·ən]
(microbiology)
A complex antibiotic substance produced by Streptomyces orientalis; useful for treatment of severe staphylococcic infections.
References in periodicals archive ?
However, after third week, when vancomycin was added to dressings, the surface area of wounds started to decrease from average 0.6 cm2 to -0.08 cm2 and 0.6cm2 in last week.
In order to assist patients and prescribers with dosing flexibility, the company will now commercialise Vancomycin for Oral Solution with a mixed berry flavour in three packaging configurations: 80 ml, 150 ml and 300 ml.
Vancomycin, a glycopeptide antibiotic, has been considered as a first line drug to treat serious gram-positive infections involving methicillin-resistant Staphylococcus aureus (MRSA) and enterococcal infections1.
Despite the vital role of vancomycin in the treatment of MRSA infections, a complete consensus has not been reached regarding the optimum dosing regimens and PK/PD goals in critically ill patients.
Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients?
Various factors that increase the risk of infection with VRE in a medical intensive care unit (ICU) include prolonged hospitalisation, younger age, use of ceftriaxone and vancomycin.18 Hospital workers can also transmit VRE as it can survive on fingers for about 30 minutes even after washing hands.8 Companion animals and pets can also be a reservoir for VRE.19 A recent report revealed the frequency of vancomycin-resistant enterococci to be 11.3% from a tertiary care hospital of Pakistan.20
E-Test Method: (The Vancomycin and Teicoplanin Minimum Inhibitory Concentration (MIC) for all the Methicillin Resistant CoNS Isolates were tested by E-Test Method)
In recent years, there have been some retrospective studies that showed high rates of acute kidney injury (AKI) in patients receiving vancomycin and piperacillin-tazobactam concomitant therapy which are higher than those reported for patients receiving vancomycin alone [8-12].
aureus (MRSA), which were nonsusceptible to daptomycin, linezolid, or vancomycin, were obtained from Eurofins repository or from the National Institutes of Health Network on Antimicrobial Resistance to Staphylococcus aureus (NARSA) repository.

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