'There are currently limited non-hormonal options for managing vasomotor
symptoms, which can be quite disruptive and often interfere with daily life,' said Salim Mujais, M.D., Senior Vice President and Therapeutic Area Head, Medical Specialties, Astellas.
It also offered access to an online tool that provided information about systemic hormone therapy, nonhormone prescription therapy, topical hormone treatment, and nonprescription treatment for vasomotor
and genitourinary symptoms of menopause.
Bijuva is the first and only FDA-approved bio-identical hormone therapy combination of estradiol and progesterone in a single, oral capsule for the treatment of moderate-to-severe vasomotor
symptoms (commonly known as hot flashes or flushes) due to menopause in women with a uterus.
symptoms: bioflavonoids, soy supplements, vitamin E, gamma-oryzonol, grape seed extract, pine bark, fish oils.
On the Greene climacteric scale, only vasomotor
symptoms were observed to be significantly high in the perimeno-pause group compared to the other groups (p<0.05).
In the article entitled "Management of Menopause Symptoms with Acupuncture: An Umbrella Systematic Review and Meta-Analysis", researchers conducted a thorough review of studies that assessed the effectiveness of acupuncture for vasomotor
symptoms and any adverse effects of treatment in perimenopause and postmenopausal women.
"The risk factors identified for poor sleep, depression, and vasomotor
symptoms, were consistently associated with poor sleep throughout the menopausal transition," the authors write.
A 2014 Cochrane meta-analysis of 5 RCTs with a total of 733 patients examined the effectiveness of any type of exercise in decreasing vasomotor
symptoms in perimenopausal and postmenopausal women.
For patients with particularly bothersome vasomotor
domain scores ranged from 6.9 to 7.2 at baseline and were 2.8-3.6 with TX-001HR and 4.4 with placebo at month 12, according to Dr.
Its lead investigational candidate, fezolinetant, is a selective NK3 receptor antagonist, and the positive data from a Phase 2a study result for the non-hormonal treatment of menopause-related vasomotor
symptoms was announced in January 2017.
Several herbal remedies, but not Chinese medicinal herbs, were associated with an overall decrease in the frequency of vasomotor
Patients with an anteroposterior deviation were not included in this study, nor were patients with vasomotor
rhinitis, allergic rhinitis, nasal polyposis, turbinate pathologies, or a systemic disease; also excluded were patients who were taking any medication and those who had undergone any previous nasal surgery.