veratrine


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veratrine

[′ver·ə‚trēn]
(materials)
An alakaloid mixture from the seeds of sabadilla (Schoenocaulon officinale); which is toxic, colorless, soluble in alcohol and ether, very slightly soluble in water, and melts at about 150°C; used in medicine. Also known as veratria.
References in periodicals archive ?
The preparations were preincubated with [Ca.sup.2+]-free Krebs' Ringer solution containing 0.1 mM EGTA or verapamil (1 X [10.sup.-5] M), a [Ca.sup.2+] channel blocker, before administration of 1 X [10.sup.-5] g/ml veratrine.
Ryanodine (1 x [10.sup.-5] M), an intracellular [Ca.sup.2+] blocker, and paeoniflorin (1 x [10.sup.-4] M) were added 20 min and 10 min, respectively, before administering veratrine (1 x [10.sup.-5] g/ml), or simultaneously.
Paeoniflorin (Nacalai Tesque Japan), veratrine hydrochloride (Sigma, USA), verapamil hydrochloride (Sigma USA), ethylene glycol-bis([beta]-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA)(Sigma USA), naloxone (Sigma USA), ryanodine (RBI USA), norepinephrine (RBI USA) and potassium chloride (Merck USA) were dissolved in Krebs' Ringer solution.
Paeoniflorin (1 x [10.sup.-4] x [10.sup.-2] M) had no effect on isolated rat and mouse vas deferens (data are not shown), but veratrine (1 x [10.sup.-5]-1 x [10.sup.-3] g/ml) induced contraction of both the epididymal and the prostatic portions of isolated mouse vas deferens (Fig.
As Tables 1 and 2 show, the phasic contractions induced by veratrine were concentration-dependent.
Ryanodine (1 x [10.sup.-5] M) decreased the contraction induced by veratrine (1 x [10.sup.-5] g/ml) in both the epididymal and the prostatic portions of isolated mouse vas deferens (Fig.
Various concentrations of veratrine (1 x [10.sup.-5] g/ml~1 x [10.sup.-3] g/ml) evoked contraction of both the epididymal and the prostatic portions of isolated mouse vas deferens in a dose-dependent manner.