Clinically, verrucous carcinoma
and giant condyloma acuminatum share many common features including large tumor size, verrucous surface, exophytic and endophytic growth, typically slow progression, and virtual lack of metastatic potential.
Differential diagnoses in the histopathological examination should include keratosis, squamous papilloma, verrucous hyperplasia, and verrucous carcinoma
Most common subtype is the conventional squamous cell carcinoma, accounting for 90% of the cases, while other relatively common types are Verrucous carcinoma
, Papillary squamous cell carcinoma, Basaloid squamous cell carcinoma, Acantholytic squamous cell carcinoma, Spindle cell carcinoma and Adenosquamous carcinoma.7
is a subtype of squamous cell carcinoma presenting with exophytic, cauliflower-like lesions similar to large warts (12).
Schwartz, "Verrucous carcinoma
of the skin and mucosa," Journal of the American Academy of Dermatology, vol.
Metastatic rate of papillary carcinoma, NOS, is similar to WC and higher than verrucous carcinomas
but lower than usual SCs .
of the foot associated with human papillomavirus type 16.
Low prevalence of high risk genotypes of human papilloma virus in normal oral mucosa, oral leukoplakia and verrucous carcinoma
. Acta Odontol Scand 2011 Nov; 69(6):406-409.
When carcinoma develops, squamous cell carcinoma is the most common (keratinizing or nonkeratinizing), while mucoepidermoid carcinoma, verrucous carcinoma
, adenocarcinoma, and undifferentiated carcinoma may be seen.
Focal epithelial hyperplasia, oral squamous papilloma, oral lichen planus, oral leukoplakia, oral verrucous carcinoma
and oral squamous carcinoma should be considered in the differential diagnosis of VV Focal epithelial hyperplasia affects oral mucosa, lips, tongue, notably lower lip and more rarely the palate and it is strongly associated with HPV types 13 and 32 .
is a well-differentiated squamous cell carcinoma with a distinct verrucous or exophytic appearance characterized by locally aggressive but minimal metastatic potential.