It also plays an important role in cholesterol homeostasis and vesicular transport
, but could also combine with a variety of signaling molecules which would activate or inhibit different intracellular signaling pathways, and regulate the expression of related genes (Fridolfsson et al.
A long-standing question in cell biology has been how membrane-rich mitochondria receive lipids synthesized in the ER in the absence of vesicular transport
between the two organelles.
39%); intracellular trafficking, secretion, and vesicular transport
As noted, a major development in his career occurred when George Palade of the Rockefeller University was invited to give a talk at Harvard in which he first demonstrated vesicular transport
at the ultrastructural level.