As it is evident from Table 1, the presence of one or more of the above conditions can be suspected when progressive psychomotor retardation,
visceromegaly, facial dysmorphism, skeletal abnormalities, or ocular findings are present.6
No lymphadenopathy or
visceromegaly. On investigations, he was confirmed to have APL (see Table 1).
Height, weight, blood pressure and urine analysis; evidence of corneal opacification should be sought; oculomotor gaze palsies and pingueculae; presence of jaundice, pallor, ecchymoses, purpura and petechiae; spinal deformity, defects of joint movement particularly hip assessment; presence of
visceromegaly (hepatosplenomegaly) and signs of chronic liver disease; neurological evaluation to include symptoms of parkinsonism for evaluation of type of Gaucher disease; and quality of life questionnaire.
The abdomen was soft, painful on palpation, with no epigastric
visceromegaly. The lower limb extremities showed mild grade II edema, bilateral inguinal lymphadenopathy of 5 cm, painful on palpation.
Right hypochondrium was especially examined for assessment of Murphy's sign, palpable mass and
visceromegaly. Systemic review was also done to see any co-morbidity.
Foam-cell infiltration and
visceromegaly are common features in all forms, but neurologic involvement occurs only in types A and C and not in type B.
ART-naive HIV-positive children with large
visceromegaly or l ymph nodes
She had neither lymphadenopathy nor
visceromegaly. Diagnostic testing found leukocyte count 12,600 cells/[mm.sup.3], CD4+ cells within normal limits, and no immunosupression.
Abdomen was soft and depressible with no tenderness or palpable masses or
visceromegaly. The rest of the physical examination was unremarkable except for a slow ambulation with the help of a cane.
(40,41) The
visceromegaly and hematologic abnormalities usually respond quite well to this treatment within one year.
ISSD is clinically distinct and very serious (1, 2);
visceromegaly, coarse facial features, failure to thrive, and early death are its main features.