The review gives many classical references such as the studies of Wolbach & Howe (1925) on the effects of vitamin A and the skin, and deals with the issue from a cosmetic point of view, ignoring the use of retinoids in dermatological treatment (even the use of all-trans-retinoic acid [ATRA] for acne).
It has long been known that vitamin A affects immune status and it has been asked whether vitamin supplementation can affect the progression of AIDS or its transmission from mother to infant.
Nine participants in the vitamin A
group responded, compared with one in the placebo group.
Earlier work by Stephensen and others in the 1990s suggested that, although vitamin A
enhanced kids' recovery from measles and other infections, it did not help, or perhaps even slowed, their recovery from bacterial pneumonia.
In animals pretreated with vitamin A
for one day to five weeks prior to carbontetrachloride exposure, Sipes says, "the previously minimal injury has exploded to look like we've given a huge dose of carbon tetrachloride.
To make the water-soluble forms, Barua attached either glucose or glucoronic acid to vitamin A
or its metabolite, retinoic acid.
Studying bovine papillomaviruses in mouse-cell cultures, the Vancouver group also discovered that a vitamin A
relative called retinoic acid reduces viral DNA inside cells.