folic acid

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Related to Vitamin B9: vitamin C, vitamin B12

folic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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Folic Acid


(vitamin Bc, pteroylglutamic acid), a vitamin of the B group. One folic-acid molecule is composed of a pteridine nucleus and para-aminobenzoic and glutamic-acid residues. The pale yellow hygroscopic crystals, which decompose at 250°C, are poorly soluble in water (0.001 percent). Folic acid is widely distributed in nature and is present in all animal, plant, and bacterial cells. It is synthesized by most microorganisms and lower and higher plants. It is not formed in the tissues of man, mammals, and birds and therefore should be obtained through food; however, it may be synthesized by microflora in the intestines.

Folic acid stimulates hematogenic functions in the organism. In animal and plant tissues it takes part—in reduced form, that is, in the form of tetrahydrofolic acid and its derivatives—in the synthesis of purine and pyrimidine bases, certain amino acids (se-rine, methionine, histidine), choline, and other compounds. The adult daily folic-acid requirement is 0.2–0.4 mg. The primary sources of the vitamin are leafy vegetables, liver, and yeast; strawberries are also a rich source.

Folic acid is effective in the treatment of certain forms of anemia and other diseases. It is prepared by the condensation of 2, 4, 5-triamino-6-hydroxy pirimidine, 1,1, 3-trichloroacetone, and para-aminobenzoyl glutamic acid. Aminopterin and methotrexate, which have a structure similar to that of folic acid, are used in the treatment of certain types of malignant tumors. These compounds are antimetabolites of folic acid and have a suppressive effect on cell growth and development.


Andreeva, N. A. Vitaminy gruppy folievoi kisloty. Moscow, 1963.
Berezovskii, V. M. Khimiia vitaminov, 2nd ed. Moscow, 1973.
Vitaminy. Edited by M. I. Smirnov. Moscow, 1974.
Blakley, R. L. The Biochemistry of Folic Acid and Related Pteridines. Amsterdam-London, 1969


folic acid

[′fō·lik ′as·əd]
C19H19N7O6 A yellow, crystalline vitamin of the B complex; it is slightly soluble in water, usually occurs in conjugates containing glutamic acid residues, and is found especially in plant leaves and vertebrate livers. Also known as pteroylglutamic acid (PGA).
References in periodicals archive ?
As regards the micronutrients of Employees 2 and 3, it was notorious that some were below recommendations, such as fibers, calcium, iron, magnesium, manganese, potassium, sodium, vitamin A, vitamin C, vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B6 (pyridoxine), vitamin B9 (folate), vitamin E and vitamin D (Table 4).
(2,13) Folate, once also known as vitamin B9, exists in foods, yet crystalline folic acid does not.
Some of the vitamins found in fruits include vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B9, vitamin C.
Department of Agriculture (USDA), also found that in women, but not men, low levels of folate (vitamin B9) were associated with depression.
Folic acid and Vitamin B9 are essential in sustaining good health because they create and maintain new cells.
One of the most important B vitamins is folic acid, or vitamin B9. It is an important nutrient for women who may become pregnant (vitamin B9 blood levels fall during pregnancy).
Following irradiation, scientists tested leaf tissues for concentrations of vitamins C, E, K and folate (sometimes called vitamin B9) and the four carotenoids: lutein/zeaxanthin, neoxanthin, violaxanthin and beta-carotene.
Green leafy vegetables such as spinach, turnips and lettuces are rich sources of folic acid, which is also commonly known as vitamin B9, it was said.
VITAMIN B9 Also known as folic acid, vitamin B9 helps give you energy and is used in the formation of blood cells.
A study of 8,000 people ages 2 to 85 has found that folic acid -- or vitamin B9 -- may help reduce allergies and asthma, reports Medical News Today.
The study included 3,096 people with coronary artery disease, three-quarters of whom were given various doses of vitamins B6, B12 and folic acid (vitamin B9), while the rest received a placebo.
There is also evidence that supra-high dose resveratrol inhibits the absorption of folic acid (vitamin B9), an essential nutrient needed for DNA repair.