warfarin


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warfarin

(wôr`fərĭn), anticoagulantanticoagulant
, any of several substances that inhibit blood clot formation (see blood clotting). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other
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 used to treat blood clots. In large doses it causes bleeding, and in patients with genetic variations that increase sensitivity to the drug and decrease the rate at which it is metabolized standard dosages may also cause bleeding. Warfarin, mixed with bait, is used in rodent control.
References in periodicals archive ?
In a project executed by PhD student Johan Holm, the initiation of amiodarone, an inhibitor of several enzymes of importance for the clearance of warfarin, instead resulted in an increased anticoagulant effect (INR > 3) in one individual out of three [2].
A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement.
Drugs: A commercial preparation of warfarin tablets 1 mg and caffeine in the form of white crystalline powder (up to 99% pure) was arranged from local market of district Faisalabad.
DOACs Warfarin can be an inconvenient drug due to the precautions and blood tests required while taking it.
Despite the excitement over DOACs, warfarin remains the first choice for certain patients.
The practice of self-testing at home to monitor warfarin patients isn't yet commonplace, although it is in a position to become more mainstream.
Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham atrial fibrillation treatment of the aged study, BAFTA): A Randomised controlled trial.
KEYWORDS: International normalized ratio, Nursing, Patient education, Randomized controlled trial, Warfarin.
The study followed over 75,000 person-years of active warfarin therapy (more than 52,000 person-years in the Medicaid cohort and more than 23,000 person-years in the Medicare cohort).
Finally, when we evaluated to association between the average warfarin dosage of the patients and the gene polymorphism by logistic regression analysis, we did not find any correlation (p=0.2).
Warfarin works by inhibiting the vitamin K-dependent activation of coagulation factors II, VII, IX, and X.
Total 76 patients were included according to warfarin dose response in warfarin therapy patients, i.e.

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