xanthine oxidase


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xanthine oxidase

[′zan‚thēn ′äk·sə‚dās]
(biochemistry)
A flavoprotein enzyme catalyzing the oxidation of certain purines.
References in periodicals archive ?
The xanthine oxidase inhibitor febuxostat, 80 mg/d or 120 mg/d (the latter an investigational dose but recommended by ACR and EULAR when needed) has demonstrated superior urate-lowering efficacy compared with allopurinol at a fixed dosage of 300 mg/d (table).
Suita, "The relationship between the adenine nucleotide metabolism and the conversion of the xanthine oxidase enzyme system in ischemia-reperfusion of the rat small intestine," Journal of Pediatric Surgery, vol.
Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach.
Terminalia bellerica is a tannin-rich extract that appears to inhibit xanthine oxidase, an enzyme involved in uric acid synthesis.
For xanthine oxidase inhibitory assay, among different classes of flavonoids, only flavonol (quercetin and kaempferol) expressed significant xanthine oxidase inhibitory effect.
In rodent models of PAH several enzymatic sources being responsible for increased ROS production have been identified such as the NADPH oxidase (Nox), xanthine oxidase (XO), an uncoupled endothelial NO synthase (eNOS), and mitochondria [10-14].
These data strongly indicate that the actual effect of SM aqueous extract in vivo is considerably stronger than in vitro, as the prodrug flavonoid glycosides, which were inactive in the applied enzyme assay, are transformed into the powerful xanthine oxidase inhibitor apigenin under physiological conditions [35].
If patients do not reach target on a xanthine oxidase inhibitor alone, lesinurad (Zur-ampic) can be added.
Comment: Xanthine oxidase is an enzyme that plays a role In the biosynthesis of uric acid.