* Vitamin B6 lowers xanthurenic acid levels to normal
To make this point clear to everyone, gestational diabetes should be re-named diabetes mellitus xanthurenica to clearly identify it's cause: excess serum xanthurenic acid. When this re-naming occurs, even conventional medicine might quit treating gestational diabetes with "diabetic diet" and insulin and actually treat the cause!
(b and c) The identification of the metabolite xanthurenic acid
by means of Q-TOF MS/MS in positive-ion mode; the positive product ion spectrum of m/z 206.0415 at 8.16 min (b) and its postulated main fragmentation pathway (c).
Baumann, "Relavtive effects of casein and trytophane on the health and xanthurenic acid excretion of pyridoxine-deficient mice," Journal of Biological Chemistry, vol.
Abnormal urinary xanthurenic acid excretion and its correction by pyridoxine," American Journal of Clinical Nutrition, vol.
Let's send a note to WebMD and the ADA: "Read the medical research!" What actually causes gestational diabetes was well researched between the 1940s and 1975, when a report (4) summarized the earlier research and then explained that gestational diabetes is caused by excessive amounts of xanthurenic acid, usually present in blood in very low levels.
That's the "genetic" part: Women who develop gestational diabetes have "weakness" in the enzymes that metabolize tryptophan into serotonin and melatonin but no weakness in the enzymes that metabolize tryptophan into xanthurenic acid. Without the pregnancy levels of estrogen "putting pressure" on these weak enzymes, they can perform as they do in most women, metabolizing tryptophan much less into xanthurenic acid and much more into many other molecules we've all heard about, including serotonin and melatonin.
Xanthurenic Acid. Xanthurenic acid (XA), a metabolite of the KP is synthesized through 3-HK transamination, and it is closely related structurally to KYNA but possesses different biological roles; actually the biological function of XA remains obscure.
Maitre, "Xanthurenic acid distribution, transport, accumulation and release in the rat brain," Journal of Neurochemistry, vol.