xenobiotic


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xenobiotic

[‚zēn·ə·bī′äd·ik]
(biochemistry)
A chemical that is not normally found in the body, such as a drug.
References in periodicals archive ?
Therefore, studies with a better study design and a larger sample size including environmental exposure data in addition to genetic variants of xenobiotic metabolism are required to provide more insight into the etiology of adult ALL.
All xenobiotic metabolism studies are performed according to OECD TG 417 (rat; OECD, 2010), 503 and 505 (farm animals; OECD, 2007a,b), 501 and 502 (plants; OECD, 2007c,d).
Next, we focused the analysis of the hepatic microarray on genes involved in xenobiotic metabolism in males compared to females.
GGT, a known marker of excessive alcohol consumption, has also been proposed as a sensitive biomarker for xenobiotic exposures and body burden.
Among the most aggressive xenobiotics on the equilibrium of ecosystems are cited some pollutants such as pesticides [1].
Absorbed MDR inhibitors become themselves targets for the classical pathways of xenobiotic detoxification/drug metabolism [27-29].
Thus, the aim of this study was to investigate the association of variant alleles in genes encoding xenobiotic metabolizing enzymes, with the hematological profiles of individuals who exhibited leukopenia.
Molecular modeling studies of CdGSTP1-1 showed similar overall fold and domain organization, however major variations were identified in C-terminal helix that may affect xenobiotic substrate recognition and catalytic mechanism.
CYP3A4 accounts for about 30% in the human hepatic metabolism of xenobiotics. The defending mechanism of drug or xenobiotic metabolizing enzymes, particularly CYP superfamily has been found to be altered by both genetic polymorphisms and the environmental factors.
Introduction: The young infant has immature kidney function, xenobiotic metabolism and gastrointestinal barrier function.
Conditions involving CKD, xenobiotic exposures that impair iron metabolism, inflammatory conditions that promote unregulated chronic cytokine activation or auto-immunity, hepatic diseases that impair iron transport and transmembrane binding, synergistic micronutrient deficiencies such as copper, excessive micronutrient competition, and dietary iron-binding interruptors explain this paradoxical phenomenon.