xenograft


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xenograft

[′zēn·ə‚graft]
(immunology)
A graft performed between members of different species.
References in periodicals archive ?
Additionally, research on STRO-001 revealed potent antitumor activity in multiple myeloma xenograft models and potent in vitro cytotoxicity in multiple non-Hodgkin lymphoma cell lines.
Based on this study, 5 g/kg MTE was used in combination with gefitinib to evaluate their anti-tumour effect on xenograft mice.
Creating this resource served us well in subsequent xenograft sequencing, as described below.
In a separate set of experiments, mice bearing human fetal testis xenografts were dosed with DBP at 0 or 500 mg/kg daily for 3 weeks, after which the xenografted samples underwent the same analyses as those from the rats.
Porcine xenograft destruction as a consequence of direct recognition of pig SLA by human T cells is likely to be a significant barrier to successful pig-to-primate xenotransplantation.
Potential xenograft recipients will be selected on the basis of their likelihood to comply with surveillance and being quarantined.
The use of non-human tissues, or xenografts, in transplantation has generally not been feasible due to the rapid (hyperacute) rejection of these non-human tissues by the human immune system.
Investigators now report that delayed xenograft rejection appears to begin when macrophages and natural killer cells infiltrate the organ.
Although some of them mildly complained about being last on the program, their personal pleas for continued research provided the best available exclamation point on the imperative to develop xenograft technologies.
This model complements Charles River's extensive portfolio of oncology products and services, including studies in human xenograft, syngeneic, and humanized immunotherapy research models, flow cytometry, and IVIS imaging services.