zinc finger


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Related to zinc finger: Leucine zipper

zinc finger

[¦ziŋk ¦fiŋ·gər]
(biochemistry)
A small structural domain that is organized around a zinc ion and is found in many gene-regulatory proteins.
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References in periodicals archive ?
We did all our tests in mouse cells because they lack all of the primate zinc finger proteins, so when you put primate retrotransposons into a mouse cell they're all active," Salama explained.
Biallelic knockout of the alpha-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases.
Sangamo's proprietary technology enables the engineering of transcription factors known as zinc finger DNA-binding proteins, or ZFPs.
To solve this problem, we explored a new application for Zinc Finger Nuclease (ZFN) technology, which enabled a technique that could revolutionize the genetic engineering of animals.
Zinc finger nucleases have edited mistakes out of cells grown in the laboratory, but no one had previously reported success with correcting typos in an animal.
The granting of this patent in the United States further expands our comprehensive intellectual property portfolio in the field of gene regulation using engineered zinc finger DNA-binding protein transcription factors for a variety of applications, including therapeutic product development," said Edward Lanphier, Sangamo's president and chief executive officer.
A position is available to study the relationships between structure and function of a recently described family of zinc finger proteins, some of whose members appear to be involved in regulating mRNA stability.
Preclinical Studies for the First Hematopoietic Stem Cell (Hsc) Gene Editing Trial: Phase 1 Study of Beta-Thalassemia with Autologous Transplantation of Zinc Finger Nuclease-Treated Hsc to Upregulate Fetal Hemoglobin -- Abstract #239 Session: Hematologic and Immunologic Diseases I Poster Session -- Wednesday, May 13, 2015
Data presented at Neuroscience 2014 demonstrate that Sangamo's zinc finger DNA-binding protein (ZFP) gene regulation technology can selectively repress expression of the mutant form of the huntingtin gene (HTT) which causes the disease, while leaving the normal gene largely unchanged in both patient-derived cells and in several mouse models.
Zinc Finger Protein Technology in Obesity Research V-30
Their presentations covered a number of therapeutic uses of Sangamo's novel zinc finger protein (ZFP) technology, but were primarily focused on reviewing the progress of the Company's ZFP Therapeutic[sup.
Kafatos and his colleagues found that the eggshell transcription factor made by fruit fly pupae has one more zinc finger than do forms of the protein made during other stages of the fruit fly life cycle.

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